HO/near-infrared light-responsive nanotheronostics for MRI-guided synergistic chemo/photothermal cancer therapy.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "HO/near-infrared light-responsive nanotheronostics for MRI-guided synergistic chemo/photothermal cancer therapy."

To develop a HO/near-infrared (NIR) laser light-responsive nanoplatform (manganese-doped Prussian blue@polypyrrole [MnPB@PPy]) for synergistic chemo/photothermal cancer theranostics. Doxorubicin (DOX) was loaded onto the surface of polypyrrole shells. The and MRI performance and anticancer effects of these nanoparticles (NPs) were evaluated. The MnPB@PPy NPs could not only generate heat under NIR laser irradiation for cancer photothermal therapy but also act as an excellent MRI contrast agent. The loaded DOX could be triggered to release by both NIR light and HO to enhance synergistic therapeutic efficacy. The antitumor effects were confirmed by cellular cytotoxicity assays and treatment in a xenograft tumor model. The designed HO/NIR light-responsive MnPB@PPy-DOX NPs hold great potential for future biomedical applications.


Journal Details

This article was published in the following journal.

Name: Nanomedicine (London, England)
ISSN: 1748-6963


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Medical and Biotech [MESH] Definitions

That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.

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That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.

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