Topics

HO/near-infrared light-responsive nanotheronostics for MRI-guided synergistic chemo/photothermal cancer therapy.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "HO/near-infrared light-responsive nanotheronostics for MRI-guided synergistic chemo/photothermal cancer therapy."

To develop a HO/near-infrared (NIR) laser light-responsive nanoplatform (manganese-doped Prussian blue@polypyrrole [MnPB@PPy]) for synergistic chemo/photothermal cancer theranostics. Doxorubicin (DOX) was loaded onto the surface of polypyrrole shells. The and MRI performance and anticancer effects of these nanoparticles (NPs) were evaluated. The MnPB@PPy NPs could not only generate heat under NIR laser irradiation for cancer photothermal therapy but also act as an excellent MRI contrast agent. The loaded DOX could be triggered to release by both NIR light and HO to enhance synergistic therapeutic efficacy. The antitumor effects were confirmed by cellular cytotoxicity assays and treatment in a xenograft tumor model. The designed HO/NIR light-responsive MnPB@PPy-DOX NPs hold great potential for future biomedical applications.

Affiliation

Journal Details

This article was published in the following journal.

Name: Nanomedicine (London, England)
ISSN: 1748-6963
Pages:

Links

DeepDyve research library

PubMed Articles [9716 Associated PubMed Articles listed on BioPortfolio]

ROS-responsive targeting micelles for optical imaging-guided chemo-phototherapy of cancer.

The combination of chemotherapy and phototherapy gives rise to a boom in cancer therapy methodology. An all-in-one nanoplatform is of particular interest for increased safety and efficacy geared towar...

InSe Nanosheets for Efficient NIR-II-responsive Drug Release.

Near-infrared-II (NIR-II) biowindow is appealing for the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug delivery na...

Multi-stimuli responsive nanosystem modified by tumor-targeted carbon dots for chemophototherapy synergistic therapy.

In this work, a tumor-targeted and multi-stimuli responsive drug delivery system combining infrared thermal imaging of cells with thermo-chemotherapy was developed. Oxidized mesoporous carbon nanopart...

Photothermal-pH-hypoxia responsive multifunctional nanoplatform for cancer photo-chemo therapy with negligible skin phototoxicity.

Highly specific and effective cancer phototherapy remains as a great challenge. Herein, a smart nanoplatform (TENAB NP) sequentially responsive to light, low pH and hypoxia is demonstrated for multi-m...

Photodynamic PEG-Coated ROS-Sensitive Prodrug Nanoassemblies for Core-Shell Synergistic Chemo-Photodynamic Therapy.

The combination of chemotherapy with photodynamic therapy (PDT) holds promising applications in cancer therapy. However, co-encapsulation of chemotherapeutic agents and photosensitizers (PS) into the ...

Clinical Trials [9680 Associated Clinical Trials listed on BioPortfolio]

Assessing Feasibility of Prolonged Repetitive Near Infrared Light Stimulation in Early to Mid-Stage Dementia

This study will gather data to see if infrared and near infrared light frequency can increase the activity of brain cells and provide support for the cell's ability to repair and protect t...

Infrared and Broadband Light for Skin Aging

In this exploratory study, we hope to learn if treatment of broadband light with infrared light can alter the molecular pathways associated with aging. Secondary exploratory objective is t...

Transcranial Near-Infrared Light in Healthy Subjects: a Cerebral Blood Flow Study With Diffuse Correlation Spectroscopy

Transcranial Light Therapy involves non-invasive and invisible beams of light that increase energy metabolism in the brain. Transcranial light therapy has been found to promote brain metab...

Infrared Transillumination of the Front of the Neck

Infrared light is applied to the front of the neck of patients for awake flexible optical intubation. The infrared light can be detected by the camera at the tip of the flexible video-bron...

NIR Fluorescence Cholangiography With Low Dose of ICG

The objective of this clinical trial is to visualize the bile ducts by injecting a contrast that is only visible with infrared light. For this, we administrate an intravenous low dose of I...

Medical and Biotech [MESH] Definitions

That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.

Techniques using energy such as radio frequency, infrared light, laser light, visible light, or acoustic energy to transfer information without the use of wires, over both short and long distances.

A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.

That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.

Measurement of the regional temperature of the body or an organ by infrared sensing devices, based on self-emanating infrared radiation.

Quick Search


DeepDyve research library

Relevant Topics

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...


Searches Linking to this Article