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Long noncoding RNA H19 regulates HIF-1α/AXL signaling through inhibiting miR-20b-5p in endometrial cancer.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Long noncoding RNA H19 regulates HIF-1α/AXL signaling through inhibiting miR-20b-5p in endometrial cancer."

In a variety of cancers, long non-coding RNAs (lncRNAs) were believed to play important roles. Nevertheless, possible molecular mechanism related to miR-20b-5p has not yet been explored in endometrial cancer. Differential lncRNAs in endometrial cancer were identified based on microarray analysis (GSE23339). In this research, in the first place, expression was detected to be increased but miR-20b-5p to be decreased in endometrial cancer tissues and cells. Besides, expression displayed a negative relationship to miR-20b-5p expression in endometrial cancer tissues. According to gain- and loss-of-function experiments of , like a ceRNA, elevated level and expression so as to stimulate the migration, proliferation and EMT process of endometrial cancer. Additionally, the knockdown of slowed down tumor growth, promoted apoptosis and upregulated miR-20b-5p expression but lowered the expressions of , PCNA and . Furthermore, was also verified to stimulate the activity of endometrial cancer with inhibitor BGB324 and . To sum up, accelerates the tumor formation of endometrial cancer through the miR-20b-5p// signaling pathway, thereby providing a novel target for diagnosing and treating endometrial cancer.

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This article was published in the following journal.

Name: Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Pages: 1-11

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