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Self-Assembled Micelles Based on Gambogenic acid-Phospholipid Complex for Sustained-Release Drug Delivery.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Self-Assembled Micelles Based on Gambogenic acid-Phospholipid Complex for Sustained-Release Drug Delivery."

To improve the water solubility and enhance the oral bioavailability of GNA(Gambogenic acid). GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. The encapsulation efficiency of GNA-PLC micelles can reach 99.33% (w/w). The average particle size of the GNA-PLC micelles was 317.7 nm which was approximate agreed with the transmission electron microscopy (TEM). release profile showed the GNA-PLC and GNA-PLC micelles have significant sustained-release of GNA compared with crude GNA. Pharmacokinetic parameters indicated that the area under concentration-time curve (AUC) of GNA in cases of GNA-PLC and GNA-PLC micelles are 2.04-fold and 3.92-fold higher than crude GNA, respectively. The better water solubility and higher bioavailability of GNA in GNA-PLC micelles with significant sustained-release of GNA endow the nanoparticle with great potential in GNA delivery system.

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This article was published in the following journal.

Name: Journal of microencapsulation
ISSN: 1464-5246
Pages: 1-27

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