Topics

Admission Plasma Uromodulin and the Risk of Acute Kidney Injury in Hospitalized Patients with Cirrhosis: a Pilot Study.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Admission Plasma Uromodulin and the Risk of Acute Kidney Injury in Hospitalized Patients with Cirrhosis: a Pilot Study."

Acute kidney injury (AKI) is a common complication in hospitalized patients with cirrhosis. Uromodulin, a protein uniquely produced by the kidney and released both in the urine and circulation, has been shown to regulate AKI and is linked to tubular reserve. Although low levels of urine uromodulin are associated with AKI after cardiac surgery, it is unclear whether circulating uromodulin can stratify the risk of AKI, particularly in a susceptible population such as hospitalized patients with cirrhosis. Thus, we investigated if plasma uromodulin measured at the time of admission, is associated with subsequent hospital acquired AKI (defined by a rise in serum creatinine >0.3mg/dL within 48 hours or -> 1.5 times baseline) in patients with cirrhosis. Ninety eight patients [mean age 54 years, Model for Endstage Liver Disease Sodium score (MELD-Na) 19, and baseline creatinine of 0.95 mg/dl] were included, of which 13% (n=13) developed AKI. Median uromodulin levels were significantly lower in patients who developed AKI compared to patients who did not (9.30 vs. 13.35 ng/mL, p=0.02). After adjusting for age, sex, diabetes, hypertension, albumin, and MELD-Na score as co-variates on multivariable logistic regression, uromodulin was independently associated with AKI [OR of 1.19 (95% CI 1.02, 1.37; p=0.02)]. Lower uromodulin levels on admission are associated with increased odds of subsequent AKI in hospitalized patients with cirrhosis. Further studies are needed to better understand the role of uromodulin in the pathogenesis and as a predictive biomarker of AKI in this population.

Affiliation

Journal Details

This article was published in the following journal.

Name: American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Pages:

Links

DeepDyve research library

PubMed Articles [27532 Associated PubMed Articles listed on BioPortfolio]

Elevated Admission Serum Calcium Phosphate Product as an Independent Risk Factor for Acute Kidney Injury in Hospitalized Patients.

Increased serum calcium-phosphate product (CaP) can result in acute kidney injury (AKI) due to tubular and interstitial calcium phosphate deposits. CaP of >55 mg/dL is also associated with systemic ca...

Risk factors for developing acute kidney injury in elderly patients

The incidence of acute kidney injury in hospitalized elderly is a frequent event that makes them prone to complications and can even lead to death. Therefore, identifying risk factors for developing a...

Comparison of impact on death and critical care admission of acute kidney injury between common medical and surgical diagnoses.

Acute Kidney Injury (AKI) is common and associated with increased morbidity and mortality. This retrospective analysis quantified and compared the association between AKI and the risk of death and adm...

Impact of the development of acute kidney injury on patients admitted to the pediatric intensive care unit.

To identify the risk factors for the development of acute kidney injury and for short and long-term mortality of patients with acute kidney injury after admission to the Pediatric Intensive Care Unit.

Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit.

AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models ...

Clinical Trials [19211 Associated Clinical Trials listed on BioPortfolio]

Assessment of Acute Kidney Injury as a Risk Factor for Myocardial Injury After Non Cardiac Surgery in Critical Patients

Acute kidney injury (AKI) affects approximately 20% of hospitalized patients and up to 67% of those admitted to an intensive care unit (ICU), making it among the most common organ dysfunct...

Prognosis of Acute Kidney Injury:China Collaborative Study on AKI(CCS-AKI)Study

Acute kidney injury (AKI) is a common clinical syndrome, especially in the hospital patients. AKI is recognized as an important risk factor for incident chronic kidney disease, accelerated...

Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury

The purpose of the study is to identify the patients at high risk of developing Acute Lung Injury (ALI) at the time of hospital admission, and before intensive care unit admission. Aim 1-...

Effect of Weekend Admission on Mortality Associated With Severe Acute Kidney Injury in England: a Propensity Score Matched, Population-based Study

Increased in-hospital mortality associated with weekend admission has been reported for many acute conditions, but no study has investigated "weekend effect" for acute kidney injury requir...

The Effect of Automated Electronic Alert for Acute Kidney Injury on the Outcomes of Hospitalized Patients

Acute kidney injury (AKI) is a common disease, but diagnosis is usually delayed or missed in hospitalized patients. The automated electronic alert for AKI may help to improve the outcomes ...

Medical and Biotech [MESH] Definitions

Abrupt reduction in kidney function defined as an absolute increase in serum CREATININE of more than or equal to 0.3. mg/dl, a percentage increase in serum creatinine of more than or equal to 50%, or a reduction in urine output. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.

The amount of PLASMA flowing to the parts of the KIDNEY that function in the production of urine. It is the amount of plasma perfusing the KIDNEY TUBULES per unit time, generally measured by P-AMINOHIPPURATE clearance. It should be differentiated from RENAL PLASMA FLOW which is approximately 10% greater than the effective renal plasma flow.

A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal failure, either acute (KIDNEY FAILURE, ACUTE) or chronic (KIDNEY FAILURE, CHRONIC), requires HEMODIALYSIS.

Requirements for the selection of students for admission to academic institutions.

Quick Search


DeepDyve research library

Relevant Topic

Blood
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...


Searches Linking to this Article