Admission Plasma Uromodulin and the Risk of Acute Kidney Injury in Hospitalized Patients with Cirrhosis: a Pilot Study.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Admission Plasma Uromodulin and the Risk of Acute Kidney Injury in Hospitalized Patients with Cirrhosis: a Pilot Study."

Acute kidney injury (AKI) is a common complication in hospitalized patients with cirrhosis. Uromodulin, a protein uniquely produced by the kidney and released both in the urine and circulation, has been shown to regulate AKI and is linked to tubular reserve. Although low levels of urine uromodulin are associated with AKI after cardiac surgery, it is unclear whether circulating uromodulin can stratify the risk of AKI, particularly in a susceptible population such as hospitalized patients with cirrhosis. Thus, we investigated if plasma uromodulin measured at the time of admission, is associated with subsequent hospital acquired AKI (defined by a rise in serum creatinine >0.3mg/dL within 48 hours or -> 1.5 times baseline) in patients with cirrhosis. Ninety eight patients [mean age 54 years, Model for Endstage Liver Disease Sodium score (MELD-Na) 19, and baseline creatinine of 0.95 mg/dl] were included, of which 13% (n=13) developed AKI. Median uromodulin levels were significantly lower in patients who developed AKI compared to patients who did not (9.30 vs. 13.35 ng/mL, p=0.02). After adjusting for age, sex, diabetes, hypertension, albumin, and MELD-Na score as co-variates on multivariable logistic regression, uromodulin was independently associated with AKI [OR of 1.19 (95% CI 1.02, 1.37; p=0.02)]. Lower uromodulin levels on admission are associated with increased odds of subsequent AKI in hospitalized patients with cirrhosis. Further studies are needed to better understand the role of uromodulin in the pathogenesis and as a predictive biomarker of AKI in this population.


Journal Details

This article was published in the following journal.

Name: American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547


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