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Supported lipid bilayers are essential model systems for studying biological membranes and for membrane-based sensor development. Surface enhanced Raman spectroscopy (SERS) stands to add considerably to our understanding of the dynamics and interactions of these systems through the direct chemical information. Despite this potential, SERS of lipid bilayers is not routinely achieved. Here, we carried out the first measurements of a solid supported lipid bilayer on a SERS-active substrate, and characterized the bilayer using SERS, atomic force microscopy (AFM), surface plasmon resonance (SPR) spectroscopy, ellipsometry, and fluorescence recovery after photobleaching (FRAP). The creation of a fluid, SERS-active supported lipid bilayer was accomplished through use of a novel silica-coated silver film-over-nanosphere (AgFON) substrate. These substrates offer a powerful new platform to couple common surface techniques that are challenging on the nanoscale, e.g. ellipsometry and FRAP, with SERS for studying biological membranes and their dynamics.
This article was published in the following journal.
Name: ACS applied materials & interfaces
: An analytical protocol based on surface-enhanced Raman spectroscopy (SERS) and aimed at the detection of toxicologically relevant concentrations of JWH-018 in oral fluid is presented for the first t...
We present an optical arrangement for spectroscopy of enhanced Raman scattering assisted by surface plasmon resonance in continuous planar metallic films. Optical excitation of propagating surface pla...
The controllable catalytic reaction plays a pivotal role in heterogeneous catalysis. Surface-enhanced Raman scattering (SERS) and tip enhanced Raman spectroscopy (TERS) are considered promising techni...
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Ex vivo vibrational spectroscopy (VS), including Raman spectroscopy (RS) of thyroid tissue samples, collected from patients undergoing routine diagnostic thyroid biopsies for diagnosis of ...
We aimed to use Raman spectroscopy to detect differences between healthy controls and patients with surgically proven endometriosis.
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The purpose of this study is to I. determine several skin parameters, for example natural moisturizing factor (NMF) and cholesterol, with Raman spectroscopy in vivo and II. compare...
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Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.
Dynamic cytoplasmic organelles found in almost all cells. They consist of a central core of LIPIDS surrounded by a phospholipid monolayer studded with surface proteins, and are involved in LIPID METABOLISM and storage.
Spectroscopy technique which measures changes in organic compounds by tracking the spectral energy of absorption of HYDROGEN atoms.
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...