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One stone with two birds: functional gold nanostar for targeted combination therapy of drug resistant Staphylococcus aureus infection.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "One stone with two birds: functional gold nanostar for targeted combination therapy of drug resistant Staphylococcus aureus infection."

The development of new antibacterial agents to deal with the emergence and spread of antibiotic resistance in Gram-positive bacterial pathogens has become an increasing problem. Here, a new strategy is developed for the effective targeting and killing of Gram-positive bacteria based on Vancomycin (Van) modified gold nanostars (AuNSs). Our work has demonstrated that Van-modified AuNSs (AuNSs@Van ) can not only selectively recognize MRSA, but also kill MRSA under NIR laser irradiation in vitro. Additionally, the AuNSs@Van shows satisfactory biocompatibility and antibacterial activity in treating bacterial infection in vivo. The attractive trait of AuNSs@Van is attributed to the physical effect of its antibacterial activity, with less potential for resistance development. The aforementioned advantages indicate the potential of AuNSs@Van as a photothermal antibacterial agent for effectively combating Gram-positive bacteria in the field of healthcare.

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This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252
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Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.

Stable gold atoms that have the same atomic number as the element gold, but differ in atomic weight. Au-197 is a stable isotope.

A suspension of metallic gold particles.

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