Quantitative Synthesis of Temperature-responsive Polymersomes by Multiblock Polymerization.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Quantitative Synthesis of Temperature-responsive Polymersomes by Multiblock Polymerization."

The current challenge for polymersomes is to prepare amphiphilic block polymers with not only well-defined molecular weight, but also precisely high-order multiblock structure in terms of the distribution of monomeric units along the chain. Here, we describe a synthesis of temperature-responsive polymersomes with precisely defined membrane structures using high-precision amphiphilic multiblock polymer via aqueous single electron transfer living radical polymerization (SET-LRP) in which poly(ethylene glycol) (PEG) macromolecules are used as initiators. We develop a one-pot, rapid and multistep sequential polymerization process with yields >99% within 30 min for each block, giving access to a wide range of high-precision multiblock polymers with very narrow molecular weight distributions (Ð ≤ 1.14). Synthesized multiblock polymers are used to form nano-sized polymersomes which are highly promising as smart carriers for high loading and triggered release of biopharmaceutics such as pharmaceutical proteins and peptides. This synthesis approach is environmentally friendly, fully translation and thus represents a significant advance in the design and synthesis of a new generation of polymer nanomaterials with precisely defined structures, which is highly attractive for applications in nanotechnology.


Journal Details

This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773


DeepDyve research library

PubMed Articles [14098 Associated PubMed Articles listed on BioPortfolio]

Synthesis of water soluble and multi-responsive selenopolypeptides via ring-opening polymerization of N-carboxyanhydrides.

We report here the synthesis of water soluble selenopolypeptides via the ring-opening polymerization of N-carboxyanhydrides. The oligoethylene glycol-bearing selenopolypeptides are thermally responsiv...

Polymersomes: Preparation and Characterization.

Polymersomes, also called polymeric vesicles, are self-assembled by amphiphilic copolymers. Due to their unique characters, polymersomes are attracting more and more interest as an important class of ...

Synthesis of Polypeptoid-Polycaprolactone-Polytetrahydrofuran Heterograft Molecular Polymer Brushes via a Combination of Janus Polymerization and ROMP.

Janus polymerization is a novel and efficient way to synthesize diblock and multiblock copolymers in one step by using Lu(OTf) and propylene epoxide as a catalytic system. By modifying the epoxide ini...

Redox-Switchable Ring-Opening Polymerization with Ferrocene Derivatives.

Switchable catalysts incorporate stimuli-responsive features and allow synthetic tasks that are difficult or impossible to accomplish in other ways. They mimic biological processes in that they can pr...

Oxidation-Sensitive Polymersomes Based on Amphiphilic Diblock Copolypeptoids.

Stimuli-responsive polymersomes formed by amphiphilic block copolymers have attracted substantial attention as smart and robust containers for drug delivery and nano/micro-reactors. Bio-sourced amphip...

Clinical Trials [2497 Associated Clinical Trials listed on BioPortfolio]

Genioglossus Strength and OSAS

Quantitative Genioglossal muscle strength in Obstructive Sleep Apnea (OSAS) defined in the clinical spectrum of subjects with Snoring Disturbance, Oral Appliance Therapy Responsive, and CP...

Postoperative Temperature Monitoring In Brain Trauma

This prospective observational study is designed to investigate the relationship between brain temperature, axillary temperature, rectal temperature, and bladder temperature of postoperati...

Clinical Investigation of a New Bulk Fill Composite Resin in the Restoration of Posterior Teeth

Polymerization shrinkage remains one of the primary disadvantages of composite resin restorative materials (tooth-colored fillings). To minimize the effects of polymerization shrinkage in ...

The Effects of Ambient Temperature and Forced-air Warming on Intraoperative Core Temperature

The purpose of this study is to determine: 1. the effect of ambient temperature on the rate of core temperature change from 1 to 3 hours after induction of anesthesia (linear phase...

Correlation Between Core Temperature and Skin Temperature in Pediatrics

During general anesthesia, temperature monitoring is critical especially in pediatrics. Recently developed 3M™ Bair Hugger™ skin temeperature which is applied on temporal artery is cor...

Medical and Biotech [MESH] Definitions

Locations, on the GENOME, of GENES or other genetic elements that encode or control the expression of a quantitative trait (QUANTITATIVE TRAIT, HERITABLE).

A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)

Measurement of the temperature of a material, or of the body or an organ by various temperature sensing devices which measure changes in properties of the material that vary with temperature, such as ELASTICITY; MAGNETIC FIELDS; or LUMINESCENCE.

Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.

Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)

Quick Search

DeepDyve research library

Relevant Topic

Nanotechnology is the engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced.  In its original sense, 'nanotechnology' refers to the projected ability to construct items fr...

Searches Linking to this Article