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Liraglutide Combined with Human Umbilical Cord Mesenchymal Stem Cell Transplantation inhibits beta-cells apoptosis via mediating the ASK1/JNK/BAX pathway in rats with Type 2 Diabetes Mellitus.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Liraglutide Combined with Human Umbilical Cord Mesenchymal Stem Cell Transplantation inhibits beta-cells apoptosis via mediating the ASK1/JNK/BAX pathway in rats with Type 2 Diabetes Mellitus."

Accumulating evidence suggests an association between beta-cell apoptosis and the ASK1/JNK/BAX pathway. The aim of this study was to investigate the effects of a combined therapy of liraglutide and human umbilical cord mesenchymal stem cells (hUC-MSCs) on the glucose metabolism and islet beta-cell apoptosis, and further explore its relationship to the ASK1/JNK/BAX pathway.

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This article was published in the following journal.

Name: Diabetes/metabolism research and reviews
ISSN: 1520-7560
Pages: e3212

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Medical and Biotech [MESH] Definitions

Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.

Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.

Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.

Jelly-like connective tissue of the UMBILICAL CORD that contains MESENCHYMAL STROMAL CELLS.

Endothelial cells that line venous vessels of the UMBILICAL CORD.

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