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In the last 15 years, scientists have used DNA as a scaffold to stabilize small, atomically monodisperse silver nanoclusters. These DNA-templated nanoclusters have attracted a lot of attention due to their intriguing photophysical properties. Here, we describe the crystal structure of a DNA-encapsulated, near-infrared emitting Ag16 nanocluster (DNA-Ag16NC) determined by X-ray analysis. The asymmetric unit of the crystal contains two DNA-Ag16NCs and the crystal packing between DNA-Ag16NCs is promoted by several interactions, such as two silver-mediated base pairs between 3'-terminal adenines, phosphate-Ca2+-phosphate interaction and π-stacking between two neighboring thymines. The individual Ag16NC is confined by two DNA decamers that take on a horse-shoe-like conformation. The tight wrapping of the two DNA strands around the cluster indicates that the Ag16NC is almost fully shielded from the solvent environment. The reported structural insight will enable to decipher the structure/photophysical property relationship for this class of emitters and open up a myriad of new research opportunities in fluorescence imaging and sensing using noble metal clusters in general.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
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Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training
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The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
The use of a quartz crystal microbalance for measuring weights and forces in the micro- to nanogram range. It is used to study the chemical and mechanical properties of thin layers, such as polymer coatings and lipid membranes; and interactions between molecues.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
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