Multicomponent aromatic and benzylic Mannich reactions through C-H bond activation.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Multicomponent aromatic and benzylic Mannich reactions through C-H bond activation."

Multicomponent Mannich reactions through C-H bond activation is described. These transformations allowed the straightforward generation of densely substituted benzylic and homo-benzylic amines in good yields. The reaction involves a reaction between two transient species: an organometallic species, generated by transition metal-catalyzed sp2 or sp3 C-H bond activation and an in situ generated imine. The use of an acetal as an aldehyde surrogate was found essential for the reaction to proceed. The process could be successfully applied to Rh(III)-catalyzed sp2 C-H bond functionalization and extended to Cu(II)-catalyzed sp3 C-H bond functionalization.


Journal Details

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Name: Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765


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