Ln-γ 2 chain of laminin-332 is a useful marker in differentiating between benign and malignant sclerosing adnexal neoplasms.

08:00 EDT 20th August 2019 | BioPortfolio

Summary of "Ln-γ 2 chain of laminin-332 is a useful marker in differentiating between benign and malignant sclerosing adnexal neoplasms."

Laminin (Ln)-γ 2, one of the chains of Ln-332, is a marker of invasive tumors and is frequently expressed as a monomer in malignant tumors. Desmoplastic trichoepithelioma (DTE), some types of BCC (infiltrating and morphoeic BCC), and microcystic adnexal carcinoma (MAC) belong to a group of tumors known as sclerosing adnexal neoplasms, that are frequently difficult to differentiate and often require immunohistochemistry for diagnosis. The aim of this study was to assess the usefulness of Ln-γ 2 expression in the differential diagnosis of DTE, infiltrating/morphoeic BCC, MAC, and syringoma.


Journal Details

This article was published in the following journal.

Name: Histopathology
ISSN: 1365-2559


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