Enantioselective Organocatalytic Desymmetrization of Cyclopentene-1,3-diones through Formal C(sp)-H Amidation.

08:00 EDT 21st August 2019 | BioPortfolio

Summary of "Enantioselective Organocatalytic Desymmetrization of Cyclopentene-1,3-diones through Formal C(sp)-H Amidation."

An enantioselective organocatalytic desymmetrization of 2,2-disubstituted cyclopentene-1,3-diones via a formal C(sp)-H amidation is reported. The reaction was carried out with -methoxy amide as the nitrogen source and commercially available cinchonidine as the catalyst under mild reaction conditions, releasing methanol as the only byproduct. It provides an efficient way to synthesize enantioenriched chiral cyclopentenyl amines bearing an all-carbon quaternary stereogenic carbon center.


Journal Details

This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904


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Medical and Biotech [MESH] Definitions

Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.

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