The roles of TG-interacting factor in cadmium exposure-promoted invasion and migration of lung cancer cells.

08:00 EDT 19th August 2019 | BioPortfolio

Summary of "The roles of TG-interacting factor in cadmium exposure-promoted invasion and migration of lung cancer cells."

Cadmium (Cd) is an established human carcinogen. Previous documents have demonstrated the association of Cd exposure with lung cancer progression. However, the underlying mechanisms of Cd-promoted invasion and migration of lung cancer cells have not yet been fully understood. The objective of this study was to explore the functional roles of TG-interacting factor (TGIF) in Cd exposure-promoted invasion and migration of lung cancer cells. Lung cancer cells were exposed to Cd for eight weeks. Invasion assay and migration assay were used to evaluate the cell invasive and migratory ability. qRT-PCR and western blot analyses were applied to analyze the expression levels of mRNA and protein. Our results showed that Cd-exposed lung cancer cells expressed markedly increased TGIF protein and mRNA compared to control cells. Cd-exposed lung cancer cells exhibited higher migratory and invasive ability than control cells did. However, silencing TGIF blocked Cd exposure-accelerated lung cancer cell invasion and migration. In addition, we found that the upregulation of Snail protein expression induced by exposure to Cd was modulated by TGIF in lung cancer cells. In conclusion, our data demonstrated that TGIF might play a crucial role in invasion and migration of lung cancer cells exposed to Cd.


Journal Details

This article was published in the following journal.

Name: Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Pages: 104630


DeepDyve research library

PubMed Articles [20195 Associated PubMed Articles listed on BioPortfolio]

Involvement of twist in NNK exposure-promoted lung cancer cell migration and invasion.

Nicotine-derived nitrosamine ketone (NNK), one of the potent carcinogens in cigarette smoke, has been reported to facilitate lung cancer cell migration and invasion. Twist plays an important role in r...

Inhibition of ROS/NUPR1-dependent autophagy antagonises repeated cadmium exposure -induced oral squamous cell carcinoma cell migration and invasion.

Cadmium (Cd), an established carcinogen, is a risk factor for oral squamous cell carcinoma (OSCC). Macroautophagy/autophagy is proposed to play a pivotal role in Cd-mediated carcinogenic activity. How...

The long non-coding RNA, urothelial carcinoma associated 1, promotes cell growth, invasion, migration, and chemo-resistance in glioma through Wnt/β-catenin signaling pathway.

The long non-coding RNA, urothelial carcinoma associated 1 (UCA1) has been demonstrated to play important roles in various types of cancers. This study investigated the functional role of UCA1 in glio...

Carvacrol inhibits cadmium toxicity through combating against caspase dependent/independent apoptosis in PC12 cells.

Carvacrol is a monoterpenic phenol found in essential oils, is considered a safe food additive, and possesses various therapeutic properties. Numerous studies have also deciphered the protective role ...

miR-155 is high-expressed in polycystic ovarian syndrome and promotes cell proliferation and migration through targeting PDCD4 in KGN cells.

Polycystic ovarian syndrome (PCOS) is a typical disease of female endocrine and metabolic abnormalities. miR-155, famous as a multifunctional miRNA, promotes the proliferation, migration and invasion ...

Clinical Trials [5764 Associated Clinical Trials listed on BioPortfolio]

PTEN and IGFBP-3 Correlation in Ovarian Carcinoma Invasion

We have identified insulin-like growth factor binding protein (IGFBP)-3 as an invasion suppressor gene in ovarian endometrioid carcinoma, and showed association with lower cancer migration...

Crab and Health Study

The brown meat from crab may contain high levels of the heavy metal cadmium. Cadmium is found in the environment and long-term exposure can cause accumulation in the body. High cadmium lev...

Vanadium in Late-onset Preeclampsia

Introduction: Cadmium, lead and vanadium important pollutants produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in a lot of studies. However, the c...

Macrophage Migration Inhibitory Factor for Diagnosing Endometriosis and Its Severity

Endometriosis is a chronic disease affecting women of reproductive age. Macrophage migration inhibitory factor (MIF) is one of non-invasive blood biomarker that was detected in sera of end...

A Study of PF-04217903 in Patients With Advanced Cancer

PF-04217903 may work in cancer by blocking the cell growth, migration and invasion of tumor cells. PF-04217903 is a new member in a class of drugs called c-Met/hepatocyte growth factor re...

Medical and Biotech [MESH] Definitions

Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.

Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.

Inorganic compounds that contain cadmium as an integral part of the molecule.

An RNA POLYMERASE II specific transcription factor. It may play a role in transcriptional activation of gene expression by interacting with the TATA-BOX BINDING PROTEIN component of TRANSCRIPTION FACTOR TFIID.

An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.

Quick Search

DeepDyve research library

Relevant Topics

Lung Cancer
Lung cancer is the uncontrolled cell growth in tissues of the lung. Originating in the lungs, this growth may invade adjacent tissues and infiltrate beyond the lungs. Lung cancer, the most common cause of cancer-related death in men and women, is respons...

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity.  This can be a drug or biochemical substance or a cell in an organism or organic sample. ...

Searches Linking to this Article