Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model.

08:00 EDT 24th August 2019 | BioPortfolio

Summary of "Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model."

Food allergy is associated with a high personal health and economic burden. For immunomodulation towards tolerance, food compounds could be chemically modified, e.g. by posttranslational protein nitration, which also occurs via diet-derived nitrating agents in the gastrointestinal tract.


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This article was published in the following journal.

Name: Allergy
ISSN: 1398-9995


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Medical and Biotech [MESH] Definitions

CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.

Digestive system disorder where a particular food irritates the digestive tract or cannot be properly digested (i.e., due to a lack of a digestive enzyme). It differs from FOOD HYPERSENSITIVITY which is an immune system disorder, usually due to specific proteins in food.

Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.

A subclass of c-ets proto-oncogene proteins that were first described by their property of binding to DNA when associated with other regulatory proteins such as SERUM RESPONSE FACTOR. They contain an amino-terminal ets domain that binds to DNA along with centrally located SERUM RESPONSE FACTOR interacting domain, and carboxy-terminal map kinase activation domains. They play an important role in transcriptional regulation by INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.

Substances that are recognized by the immune system and induce an immune reaction.

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Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...

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