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The various and shared roles of lncRNAs during development.

08:00 EDT 27th August 2019 | BioPortfolio

Summary of "The various and shared roles of lncRNAs during development."

lncRNAs, genes transcribed but not translated, longer than 200 nucleotides, are classified as a separate class of non-protein coding genes. Since their discovery, largely from RNAseq data, a number of pioneer studies has begun to unravel its myriad functions, centered on gene expression regulation, suggesting developmental and evolutionary conservation. Since they do not code for proteins and have no open reading frames, their functional constraints likely differ from that of protein coding genes, or of genes where the majority of the nucleotide sequence is required for function, like tRNAs. This has complicated assessment of both developmental and evolutionary conservation, and the identification of homologs in different species. Here we argue that other characteristics: general synteny and particular chromosomal placement regardless of sequence, sequence micro-motifs, and secondary structure allow for "homologs" to be identified and compared, confirming developmental and evolutionary conservation of lncRNAs. We conclude exemplifying a case in point: that of the evolutionarily conserved lncRNA acal, characterized and required for embryogenesis in Drosophila. This article is protected by copyright. All rights reserved.

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Name: Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
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