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The compositions of injectable poly-D,L-lactic acid and injectable poly-L-lactic acid.

08:00 EDT 30th August 2019 | BioPortfolio

Summary of "The compositions of injectable poly-D,L-lactic acid and injectable poly-L-lactic acid."

Injectable poly-L-lactic acid (PLLA) was first available in Europe in 1999. It was approved by US FDA for facial filling of lipotrophic HIV patients in 2004 (Sculptra; Dermik Laboratories, Bridgewater, NJ), and then the use of injectable PLLA was further expanded to facial cosmetic applications in 2009. Injectable poly-D,L-lactic acid (PDLLA) is a new sub-dermal filler (AestheFill; REGEN Biotech, Inc., Seoul, South Korea). It was first approved by Korean FDA in 2014. The clinical trials of injectable PDLLA were performed in Korea by Hyun et al. The study was published in Clinical and Experimental Dermatology entitled as "Efficacy and safety of injection with poly-L-lactic acid compared with hyaluronic acid for correction of nasolabial fold: a randomized, evaluator-blinded, comparative study". This article is protected by copyright. All rights reserved.

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Name: Clinical and experimental dermatology
ISSN: 1365-2230
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Medical and Biotech [MESH] Definitions

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

A species of gram-positive, rod-shaped LACTIC ACID bacteria that is frequently used as starter culture in SILAGE fermentation, sourdough, and lactic-acid-fermented types of beer and wine.

Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as diabetes mellitus, leukemia, or liver failure.

The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.

A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.

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