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Advances and Challenges of CAR T Cells in Clinical Trials.

07:00 EST 1st January 2020 | BioPortfolio

Summary of "Advances and Challenges of CAR T Cells in Clinical Trials."

As a specifically programmable, living immunotherapeutic drug, chimeric antigen receptor (CAR)-modified T cells are providing an alternative treatment option for a broad variety of diseases including so far refractory cancer. By recognizing a tumor-associated antigen, the CAR triggers an anti-tumor response of engineered patient's T cells achieving lasting remissions in the treatment of leukemia and lymphoma. During the last years, significant progress was made in optimizing the CAR design, in manufacturing CAR-engineered T cells, and in the clinical management of patients showing promise to establish adoptive CAR T cell therapy as an effective treatment option in the forefront.

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This article was published in the following journal.

Name: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
ISSN: 0080-0015
Pages: 93-128

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