Bronchodilation induced by PGE is impaired in Group-III pulmonary hypertension.

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Summary of "Bronchodilation induced by PGE is impaired in Group-III pulmonary hypertension."

In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), a reduction of pulmonary vascular tone and tissue hypoxia are considered therapeutically beneficial. Prostaglandin (PG) E and PGI induce potent relaxation of human bronchi from non-PH (control) patients via EP4 and IP receptors, respectively. However, the effects of PGE /PGI and their mimetics on human bronchi from PH-patients are unknown. Our aim was to compare the relaxant effects of several PGI -mimetics approved for treating PH-Group I with several PGE -mimetics in bronchial preparations derived from PH-Group III and control patients.


Journal Details

This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381


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