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Asymmetric Palladium-Catalyzed C‒H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones.

08:00 EDT 2nd September 2019 | BioPortfolio

Summary of "Asymmetric Palladium-Catalyzed C‒H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones."

A palladium-catalyzed C‒H functionalization/intramolecular asymmetric allylation cascade of N-sulfonyl benzamides with 1,3-dienes has been developed. In the presence of a chiral pyridine-oxazoline ligand, this protocol enables the synthesis of chiral 3,4-dihydroisoquinolones in yields of up to 83% with enantioselectivities of up to 96%, using environmentally friendly air as the terminal oxidant.

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Name: The Journal of organic chemistry
ISSN: 1520-6904
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