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Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging.

07:00 EST 1st January 2019 | BioPortfolio

Summary of "Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging."

Gut microbiota composition and functionality can influence the pathophysiology of age-related cognitive impairment and dementia, according to a large number of animal studies. The translation of this concept to humans is still uncertain, due to the relatively low number of clinical studies focused on fecal microbiota and large number of environmental factors that influence the microbiota composition. However, the fecal microbiota composition of older patients with dementia is deeply different from that of healthy active controls, conditioning a different metabolic profile. The possible use of fecal microbiota-related parameters and microbiota-derived metabolites as biomarkers of cognitive performance and dementia is critically reviewed in this paper, focusing on the most promising areas of research for the future.

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Journal Details

This article was published in the following journal.

Name: Advances in experimental medicine and biology
ISSN: 0065-2598
Pages: 129-154

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Medical and Biotech [MESH] Definitions

Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient.

A species of Bifidobacterium present in the human GUT MICROBIOTA. It is used as a PROBIOTIC.

The full collection of microbes (bacteria, fungi, virus, etc.) that naturally exist within a particular biological niche such as an organism, soil, a body of water, etc.

Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.

A phylum of predominantly GRAM-POSITIVE BACTERIA that includes the orders Bacillales and Clostridiales. Firmicutes and BACTEROIDETES are the two bacterial phyla that constitute the majority of the human gut MICROBIOTA.

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