Hematopoietic stem cell transplantation in solid organ recipients with emphasis on transplant complications: a nationwide retrospective survey on behalf of the JSHCT, transplant complications working group.

08:00 EDT 5th September 2019 | BioPortfolio

Summary of "Hematopoietic stem cell transplantation in solid organ recipients with emphasis on transplant complications: a nationwide retrospective survey on behalf of the JSHCT, transplant complications working group."

Little is known about stem cell transplantation in solid organ transplantation recipients. Thus, we conducted a nationwide retrospective survey of Japan Society for Hematopoietic Stem Cell Transplantation centers. A total of 19 patients who underwent 22 hematopoietic stem cell transplantation procedures after solid organ transplantation were identified: 5 autologous hematopoietic stem cell transplantations and 17 allogeneic hematopoietic stem cell transplantations were performed. Patients who underwent autologous hematopoietic stem cell transplantation received liver (n = 4) and kidney (n = 1) transplants. All five patients achieved neutrophil engraftment, and two of three patients with hepatoblastoma were alive 1 year after hematopoietic stem cell transplantation. Allogeneic hematopoietic stem cell transplantation was performed in 16 patients (7 with liver and 9 with kidney transplantations). Among them, two donors were identical for both transplantations. All but one patient achieved neutrophil engraftment. Five-year overall survival rate was 41.7%, but that in patients with malignant disease (n = 13) was much lower than the overall rate (23.1%). Only one patient with malignant disease received allogeneic hematopoietic stem cell transplantation in non-remission. In allogeneic hematopoietic stem cell transplantation after kidney transplantation, post-transplant (1 year) kidney function in five evaluable patients was significantly lower than that before allogeneic hematopoietic stem cell transplantation and three patients experienced renal rejection. However, no severe hepatic rejection was noted. In solid organ transplantation recipients, hematopoietic stem cell transplantation is a potentially curable treatment for hematological disorders, but it must be performed with caution, especially in cases of malignancy.


Journal Details

This article was published in the following journal.

Name: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536


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Medical and Biotech [MESH] Definitions

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.

Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.

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