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Saliva microbiome in primary Sjogren's syndrome reveals distinct set of disease associated microbes.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Saliva microbiome in primary Sjogren's syndrome reveals distinct set of disease associated microbes."

This study systematically aims to evaluate the salivary microbiome in patients with primary Sjögren's syndrome(pSS) using 16S rRNA sequencing approach.

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This article was published in the following journal.

Name: Oral diseases
ISSN: 1601-0825
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Medical and Biotech [MESH] Definitions

Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.

A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.

A solution used for irrigating the mouth in xerostomia and as a substitute for saliva.

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DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...


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