How Does Testosterone Act to Regulate a Multifaceted Adaptive Response? Lessons from Studies of the Avian Song System.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "How Does Testosterone Act to Regulate a Multifaceted Adaptive Response? Lessons from Studies of the Avian Song System."

In male songbirds, song functions to attract a mate or to defend a territory; it is therefore often produced in the context of reproduction. Testosterone of gonadal origin increases during the reproductive phase of the annual cycle and significantly enhances song production as well as song development via effects on song crystallization. The neural control of birdsong production and learning is highly modular. We implanted testosterone or androgen antagonists into specific brain regions or in the periphery of castrated male canaries and in this way identified how androgen signaling in specific locations regulates a variety of birdsong features. For example, castrated male canaries treated with testosterone in the preoptic area only and exposed to long days sing at high rates compared to castrated male canaries not treated with testosterone. However, these birds with testosterone in the preoptic area still produce songs with substantially lower song stereotypy and amplitude; these features are controlled by testosterone acting in the song control nuclei HVC and RA. Specific aspects of the learned singing behavior are thus regulated by androgens acting at multiple levels in the brain in a non-redundant fashion. Testosterone action in the preoptic area is related to the hormonal regulation of the motivation to sing but not to various aspects of song performance. Multiple aspects of song quality are instead precisely regulated by steroids acting in distinct song control nuclei. Females exert a strong choice for specific features of male song in canaries and this choice is influenced by the endocrine state of the female. The female song system is also involved in song production as well as song perception but the specificity of this hormone action has not been investigated yet.


Journal Details

This article was published in the following journal.

Name: Journal of neuroendocrinology
ISSN: 1365-2826
Pages: e12793


DeepDyve research library

PubMed Articles [12005 Associated PubMed Articles listed on BioPortfolio]

Three-month cumulative exposure to testosterone and cortisol predicts distinct effects on response inhibition and risky decision-making in adolescents.

Prior studies have established that cortisol and testosterone play a role in impulsive behavior, but little is known about how cumulative exposure to these hormones over a recent period influences cog...

Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene.

To evaluate the influence of single nucleotide polymorphisms (SNPs) of CYP19A1 on the response and susceptibility to side effects from testosterone therapy. This is a prospective, single-arm study of ...

Human Chorionic Gonadotropin monotherapy for the treatment of hypogonadal symptoms in men with total testosterone > 300 ng/dL.

The 2018 American Urological Association guidelines on the Evaluation and Management of Testosterone Deficiency recommended that 300 ng/dL be used as the threshold for prescribing testosterone replace...

Putting the Flight in "Fight-or-Flight": Testosterone reactivity to skydiving is modulated by Autonomic Activation.

Sensation-seeking (SS) involves the tendency to pursue exciting activities, potentially including risky behaviors (e.g., substance use, risky sexual behavior). Testosterone is associated with cortisol...

Evaluation of the host immune response and functional recovery in peripheral nerve autografts and allografts.

Allogeneic peripheral nerve (PN) transplants are an effective bridge for stimulating regeneration of segmental PN defects, but there are currently no detailed studies about the timeline and scope of t...

Clinical Trials [4573 Associated Clinical Trials listed on BioPortfolio]

EndogenousTestosterone Response to a Testosterone Boosting Supplement

The purpose of this study is to determine whether a proprietary 'testosterone-boosting' supplement, when used as recommended by the manufacturer, results in an increase in testosterone lev...

Testosterone Replacement in Men With Diabetes and Obesity

The purpose of this study is to examine the effect of having testosterone deficiency in men with diabetes and with obesity. The study will also evaluate the effect of testosterone therapy....

TDSM- Testosterone Dose Response in Surgically Menopausal Women

TDSM will study the physiology of testosterone in women ages 21-60 who have had surgical menopause (uterus and both ovaries removed). Testosterone is commonly thought of as a "male hormon...

Effect of Testosterone in Men With Erectile Dysfunction

The purpose of this placebo-controlled study is to determine if testosterone replacement therapy, administered by transdermal gel, can improve the response to sildenafil (Viagra R) treatme...

Subcutaneous vs. Intramuscular Testosterone

In this randomized, cross‐over study 20 subjects who are undergoing testosterone (T) therapy for the treatment of T deficiency will receive both subcutaneous testosterone therapy and int...

Medical and Biotech [MESH] Definitions

Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.

A potent androgenic metabolite of TESTOSTERONE. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to ESTRADIOL therefore DHT is considered a pure androgenic steroid.

A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

A heterogeneous, immature population of myeloid cells that can suppress the activity of T-CELLS and NATURAL KILLER CELLS in the INNATE IMMUNE RESPONSE and ADAPTIVE IMMUNE RESPONSE. They play important roles in ONCOGENESIS; INFLAMMATION; and INFECTION.

The capacity of VACCINES to stimulate the ADAPTIVE IMMUNE RESPONSE to produce antibodies and antigen-specific T-CELL responses.

Quick Search

DeepDyve research library

Relevant Topic

Diabetes Diabetes Endocrine Disorders Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several g...

Searches Linking to this Article