Biosynthesis of size-controlled gold nanoparticles using M. lucida leaf extract and their penetration studies on human skin for plastic surgery applications.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Biosynthesis of size-controlled gold nanoparticles using M. lucida leaf extract and their penetration studies on human skin for plastic surgery applications."

Recently, majority of the studies were focusing on the nanoparticles (NPs) and their abilities of penetrating Stratum Corneum (SC), as they can be prominently utilized in the plastic surgeries. In the current work, we demonstrated the penetrating abilities of gold NPs (AuNPs) through anthropological skin with diameters of 10 and 15 nm, varying in sizes, with the help of Multiphoton Microscopy. In addition, we also demonstrated a rapid facile environment friendly process of synthesizing AuNPs of adjustable sizes with the help of aqueous M. lucida leaf extract. Surface plasmon resonance was performed to confirm the synthesis of AuNPs at 530 nm with the help of UV-vis spectrophotometer. By differentiating the quantities of M. lucida leaf aqueous extracts, we studied the reduction time, morphological differences and size of the AuNPs. By performing Fourier Transformation Infrared Spectroscopy (FTIR), UV-vis spectroscopy, Transmission Electron Microscopy (TEM), Powder X-ray Diffraction (XRD), Energy Dispersive X-ray Spectroscopy (EDAX) and Selected Area Electron Diffraction (SAED), we characterized the fabricated AuNPs. The further aggregation and growth of AuNPs was protected by the polyphenols in the oxidised form by having a coordination with the surface of AuNPs. Moreover, the experiments of skin penetration showed an effort to deeply examine the factors leading to the penetration of particles into the human skin. These responses indicate that NPs at the determined size ranges penetrate the SC in the same pattern of the drug molecules, mostly by the intercellular paths. These responses attained were essential for developing a unique transdermal transporter as well as for understanding the basic interaction of skin-NPs for the application of plastic surgeries.


Journal Details

This article was published in the following journal.

Name: Journal of photochemistry and photobiology. B, Biology
ISSN: 1873-2682
Pages: 111591


DeepDyve research library

PubMed Articles [14717 Associated PubMed Articles listed on BioPortfolio]

Recruitment of various biological macromolecules in fabrication of gold nanoparticles: Overview for preparation and applications.

This review summarizes recent works for fabrication of gold nanoparticles with controlled shape, size, and functional properties using polysaccharides as superior biological macromolecules. Special co...

Ficus retusa-stabilized gold and silver nanoparticles: Controlled synthesis, spectroscopic characterization, and sensing properties.

Ficus retusa was used as reducing and stabilizing agent in the green synthesis of silver and gold nanoparticles with high dispersion stability and controllable size and shape. The controlling of react...

Hypoxia-induced biosynthesis of gold nanoparticles in the living brain.

While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose the concept of targeted biosynthesis of nanoparticles in...

Characterizing the protein corona of sub-10 nm nanoparticles.

Studies into the interactions of serum proteins with nanoparticles are typically performed using nanoparticles that are larger than the size of proteins. Due to this size discrepancy, adsorbed protein...

Biosynthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from leaf extract of Mentha pulegium (L.).

The synthesis of metal and semiconductor nanoparticles is an expanding research area due to the potential applications in the development of novel technologies. In the present study, a simple and eco-...

Clinical Trials [3918 Associated Clinical Trials listed on BioPortfolio]

Mulberry Leaf Extract and Blood Glucose Control in Diabetics

Mulberry leaf teas or extracts are used as a natural remedy for diabetes in some countries. Animal studies have shown some effect of mulberry leaf extract on blood glucose. The purpose of ...

Topical Silver Nanoparticles for Microbial Activity

Silver nanoparticles are one of most nanoparticles use nowadays in the research area because it has specific physical and chemical properties, in medical fields silver nanoparticles can in...

Presence of Nanoparticles in the Amniotic Fluid

The nanoparticles (NP) are defined as particles whose size is no greater than 100 nanometers. However, their impact on health remains little evaluated. Placental transfer of NP has been p...

Anti-diabetic Effects of Persimmon Leaf Extract

The investigators performed a 8-week, randomized, double-blind, placebo-controlled crossover human trial to evaluate the efficacy and safety of persimmon leaf extract on blood glucose. The...

Use of Banana Leaf Dressing on Donor Site Wounds

Prospective Randomized double-blind controlled trial comparing the healing rate, infection rate, pain score, ease of care and scar formation of Banana leaf dressing versus hydrocolloid dre...

Medical and Biotech [MESH] Definitions

Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.

Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.

Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.

Stable gold atoms that have the same atomic number as the element gold, but differ in atomic weight. Au-197 is a stable isotope.

A layer of protein coating adsorbed by NANOPARTICLES upon entry into PLASMA or other protein-containing biological fluids, which affects how nanoparticles are internalized by cells and cleared from the body.

Quick Search

DeepDyve research library

Relevant Topics

Wound management
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...

Searches Linking to this Article