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Recommended foscarnet dose is not associated with improved outcomes in cytomegalovirus salvage therapy.

08:00 EDT 3rd September 2019 | BioPortfolio

Summary of "Recommended foscarnet dose is not associated with improved outcomes in cytomegalovirus salvage therapy."

Cytomegalovirus (CMV) infection causes significant morbidity and mortality in transplant recipients. Ganciclovir and valganciclovir have proven efficacy but are limited by resistance and toxicity, whereas foscarnet typically retains activity when CMV has become resistant to other antivirals. Foscarnet dosing used in practice may be discordant with what is recommended in product labeling, as the result of an unconventional dosing nomogram or prescriber preference; however, it is unknown how discordant foscarnet dosing affects outcomes.

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This article was published in the following journal.

Name: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
ISSN: 1873-5967
Pages: 12-16

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Medical and Biotech [MESH] Definitions

Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.

CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.

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The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

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