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Developing near-infrared (NIR) persistent luminescence (PersL) bioprobes has attracted increasing attention due to their ultra-low autofluorescence and deep tissue penetration. Accurate imaging of glutathione (GSH) in vivo is of great significance to provide a real-time visualization of pathologies. Herein, manipulating metal ions as the switch of NIR afterglow was demonstrated to construct NIR PersL nanoprobes for the first time, which was highly efficient and much simpler than the luminescence resonance energy transfer (LRET) principle. As a proof-of-concept application, an activatable NIR PersL nanoprobe (Probe-1) built on core-shell structure was rationally fabricated for detection of GSH via employing Cu as the quencher. In light of unique NIR PersL feature and flexible functionality, Probe-1 exhibited greatly enhanced analytical performances for GSH detection, and particularly imaging of tumor in living mouse. This approach without limits of spectral overlap from the LRET principle provided a new way to develop NIR PersL bioprobes for autofluorescence-free detection.
This article was published in the following journal.
Name: Biosensors & bioelectronics
We report on the structural and optical properties of GaAs<sub>0.7</sub>P<sub>0.3</sub>/GaP core-shell nanowires (NWs) for future photovoltaic applications. The NWs are grown b...
Bioavailable persistent luminescence material is an ideal internal light source for long-term photodynamic therapy, but inevitably suffers from low utilization efficiency and weak persistent luminesce...
ZnGa2O4:Cr3+, owing to its persistent luminescence properties in the deep red range, is an exceptional material in view of foreseen in vivo imaging applications. In the present work, we report the ela...
In this study, we designed and synthesized far-red- and near-infrared-emitting Cu-doped InP-based quantum dots (QDs), and we also demonstrated their highly specific and sensitive biological imaging ab...
Although attractive for their low toxicity, CuInS/ZnS core/shell quantum dots (CIS/ZnS QDs) still suffer from poor luminescence efficiency and poor water solubility. Herein, two amino acids (AAs), i.e...
This study will be a prospective, non-randomized evaluation of the Tritanium® Primary Acetabular Shell for primary total hip replacement (THR) with a cementless application in a consecuti...
The purpose of this study is to test Cerenkov luminescence imaging, which is a different way to take pictures of thyroid cancer and/or any tumors with (existing or suspected) nodal metasta...
Patients having radiotherapy to their head and neck wear an immobilisation shell to prevent patient movement and improve treatment accuracy. These shells tend to cover the face and have th...
The purpose of this study is to review the performance and success rate of an FDA approved cementless hip replacement part called the Trident II Tritanium Acetabular Shell. The study will ...
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available G7 BiSpherical Acetabular Shell.
Measurement of the regional temperature of the body or an organ by infrared sensing devices, based on self-emanating infrared radiation.
That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A spiral tube that is firmly suspended in the bony shell-shaped part of the cochlea. This ENDOLYMPH-filled cochlear duct begins at the vestibule and makes 2.5 turns around a core of spongy bone (the modiolus) thus dividing the PERILYMPH-filled spiral canal into two channels, the SCALA VESTIBULI and the SCALA TYMPANI.
A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.