Ondansetron effects on apamin-sensitive small conductance calcium-activated potassium currents in pacing induced failing rabbit hearts.

08:00 EDT 9th September 2019 | BioPortfolio

Summary of "Ondansetron effects on apamin-sensitive small conductance calcium-activated potassium currents in pacing induced failing rabbit hearts."

Ondansetron, a widely prescribed antiemetic, has been implicated in drug-induced long QT syndrome. Recent patch clamp experiments have shown that ondansetron inhibits the apamin sensitive calcium activated potassium current (I).


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This article was published in the following journal.

Name: Heart rhythm
ISSN: 1556-3871


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Medical and Biotech [MESH] Definitions

The pore-forming subunits of large-conductance calcium-activated potassium channels. They form tetramers in CELL MEMBRANES.

A major class of calcium-activated potassium channels that are found primarily in excitable CELLS. They play important roles in the transmission of ACTION POTENTIALS and generate a long-lasting hyperpolarization known as the slow afterhyperpolarization.

The regulatory subunits of large-conductance calcium-activated potassium channels.

A major class of calcium activated potassium channels whose members are voltage-dependent. MaxiK channels are activated by either membrane depolarization or an increase in intracellular Ca(2+). They are key regulators of calcium and electrical signaling in a variety of tissues.

A major class of calcium-activated potassium channels that were originally discovered in ERYTHROCYTES. They are found primarily in non-excitable CELLS and set up electrical gradients for PASSIVE ION TRANSPORT.

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