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Slow propagations of spontaneous brain activity have been reported in multiple species. However, systematical investigation of the organization of such brain activity is still lacking. In this study, we analyzed propagations of spontaneous brain activity using a reference library of characteristic resting-state functional connectivity (RSFC) patterns in awake rodents. We found that transitions through multiple distinct RSFC patterns were reproducible not only in transition sequences but also in transition time delays. In addition, the organization of these transitions and their spatiotemporal dynamic patterns were revealed using a graphical model. We further identified prominent brain regions involved in these transitions. These results provide a comprehensive framework of brainwide propagations of spontaneous activity in awake rats. This study also offers a new tool to study the spatiotemporal dynamics of activity in the resting brain.
This article was published in the following journal.
Awake rat brain positron emission tomography (PET) has previously been developed to avoid the influence of anesthesia on the rat brain response. In the present work, we further the awake rat brain sca...
Prepulse inhibition (PPI) of startle response is a measure of sensorimotor gating that is impaired in schizophrenia and in many other clinical conditions. Rat models using pharmacological or surgical ...
The exaggerated beta synchronized oscillation in the cortico-basal ganglia circuit is a hallmark of disease-specific motor symptoms in Parkinson's disease (PD). The functional connectivity between the...
Generalized seizures engage bilateral networks from their onset at a low temporal scale. Previous studies findings have demonstrated focal/local brain activity abnormalities in the patients with gener...
Female smokers are more likely to relapse than male smokers, but little is known about sex differences in nicotine withdrawal. Therefore, male and female rats were prepared with minipumps that contain...
This study protocol examines a comparison between local and general anesthesia (Awake vs. Asleep Craniotomy) in the removal of brain tumors that are in areas of the brain that do not direc...
Certain kind of neurosurgical procedures require intraoperative alertness of the patient, for example to perform speech tests during brain tumor resection. With respect to anaesthesia, it ...
Awake intubation is a recommended safety procedure in specific cases where the intubation or ventilation before general anesthesia is at risk. Numerous techniques to allow awake intubatio...
Background: - The brain needs sleep to function normally, but the purpose of sleep is not understood. Brain activity decreases during sleep, so it may be that sleep is important t...
This study will determine whether transcranial direct current stimulation (tDCS) can be used alter the amplitude of spontaneous neural activity, and thereby modulate cognitive function in ...
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
The measurement of magnetic fields over the head generated by electric currents in the brain. As in any electrical conductor, electric fields in the brain are accompanied by orthogonal magnetic fields. The measurement of these fields provides information about the localization of brain activity which is complementary to that provided by ELECTROENCEPHALOGRAPHY. Magnetoencephalography may be used alone or together with electroencephalography, for measurement of spontaneous or evoked activity, and for research or clinical purposes.
One of four types of brain waves characterized by a relatively high voltage or amplitude and a frequency of 8-13 Hz. They constitute the majority of waves recorded by EEG registering the activity of the parietal and occipital lobes when the individual is awake, but relaxed with the eyes closed.
Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.