Real-Time Optical Redox Imaging of Cartilage Metabolic Response to Mechanical Loading.

08:00 EDT 9th September 2019 | BioPortfolio

Summary of "Real-Time Optical Redox Imaging of Cartilage Metabolic Response to Mechanical Loading."

Metabolic dysregulation has recently been identified as a key feature of osteoarthritis. Mechanical overloading has been postulated as a primary cause of this metabolic response. Current methods of real-time metabolic activity analysis in cartilage are limited and challenging. However, optical redox imaging leverages the autofluorescence of co-enzymes NAD(P)H and FAD to provide dye-free real-time analysis of metabolic activity. This technique has not yet been applied to cartilage. This study aimed to assess the effects of a compressive load on cartilage using optical redox imaging.


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This article was published in the following journal.

Name: Osteoarthritis and cartilage
ISSN: 1522-9653


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