Acceleratory effects of ambient fine particulate matter on the development and progression of atherosclerosis in apolipoprotein E knockout mice by down-regulating CD4CD25Foxp3 regulatory T cells.

08:00 EDT 9th September 2019 | BioPortfolio

Summary of "Acceleratory effects of ambient fine particulate matter on the development and progression of atherosclerosis in apolipoprotein E knockout mice by down-regulating CD4CD25Foxp3 regulatory T cells."

Atherosclerosis is an autoimmune inflammatory disease that is closely associated with long-term exposure to fine particulate matter (PM2.5). CD4CD25Foxp3 regulatory T cells (Tregs) play a critical role in the regulation of T cell-mediated immune responses, and the depletion of CD4CD25Foxp3 Tregs has been thought to play a prominent role in atherosclerosis. Therefore, we investigated the association between the CD4CD25Foxp3 Tregs population and atherosclerotic development in ApoE mice exposed to PM2.5.


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This article was published in the following journal.

Name: Toxicology letters
ISSN: 1879-3169


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