Fundamental evaluation and optimization of porous spherical silica for developing functional fine particles via fluidized bed coating.

08:00 EDT 9th September 2019 | BioPortfolio

Summary of "Fundamental evaluation and optimization of porous spherical silica for developing functional fine particles via fluidized bed coating."

Particle coating, a taste-masking technique for drugs, is limited by its long manufacturing time, which is caused by the decrease in the spray rate required to prevent particle agglomeration. Mesoporous silica particles, which have a high surface area and pore sizes in the range of 2-50 nm, possess high surface free energy; they have attracted significant interest for numerous applications in adsorption, separation, and catalysis and drug delivery. A form of mesoporous silica, microbead silicate, can prevent particle aggregation because of its good water absorbency and drying properties. Hence, it has been suggested to be applicable for particle coating. This study evaluated the physical properties and drug release capability of microbead silicate with different pore sizes. Although microbead silicate with small pores displayed a rapid drug release profile, drug release was incomplete. Contrastingly, microbead silicate with large pores achieved complete drug release even with high drug loading. Furthermore, in the case of 100% layering, the porosity of microbead silicate was maintained, thus sufficiently preventing aggregation due to the prevention of formation of liquid bridging of the coating solution. These results suggest that using microbead silicate with large pores for particle coating enables complete drug release while improving manufacturability.


Journal Details

This article was published in the following journal.

Name: International journal of pharmaceutics
ISSN: 1873-3476
Pages: 118685


DeepDyve research library

PubMed Articles [20221 Associated PubMed Articles listed on BioPortfolio]

Double-walled hierarchical porous silica nanotubes loaded Au nanoparticles in the interlayer as a high-performance catalyst.

Double-walled hierarchical porous silica nanotubes (NTs) loaded Au nanoparticles (Au NPs) in the interlayer (SiO₂@Au@SiO₂ NTs) are synthesized by using tetraethoxysilane as silica source and hollo...

Self-Assembled Porous-Silica within N-Doped Carbon Nanofibers as Ultra-flexible Anodes for Soft Lithium Batteries.

Silica is an attractive anode material for soft lithium batteries owing to its high specific capacity, but it suffers severe problems of large volume change and unstable solid-electrolyte interface. M...

Supermicroporous silica nanograins: Synthesis and application.

Supermicroporous silicas having micropores 1-2 nm in diameter were miniaturized to 30-40 nm in diameter using a combination of binary organic agents: cationic surfactant as a porogen and polyethylene ...

Molecularly imprinted polymeric shell coated monodisperse-porous silica microspheres as a stationary phase for microfluidic boronate affinity chromatography.

Molecular imprinting of cis-diol functionalized agents via boronate affinity interaction has been usually performed using nanoparticles as supports which can not be utilized as a stationary phase in c...

Boron-Doped Spherical Hollow-Porous Silicon Local Lattice Expansion toward a High-Performance Lithium-Ion-Battery Anode.

Silicon (Si) attracts extensive attention as the advanced anode material for lithium (Li)-ion batteries (LIBs) because of its ultrahigh Li storage capacity and suitable voltage plateau. Hollow porous ...

Clinical Trials [7148 Associated Clinical Trials listed on BioPortfolio]

Safety Evaluation of Porous Silica in Men

The aim of the present study was to determine whether oral dosing, up to 9 grams/day, of porous silica administered as a food additive can be used safely in normal weight and obese male hu...

A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices

The purpose of this study is to determine whether spherical silica can achieve similar or greater extrinsic dental stain and plaque removal, in comparison to dentifrices containing higher ...

Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty

The purpose of this research is to collect data on patients that had the Legion Porous HA Tibial Baseplates and/or the Legion Porous HA Femoral component implanted in the past. Smith & Nep...

Optical Quality After Implantation of a Spherical or Aspherical Intraocular Lens in Hypermetropic Patients

The purpose of this study is to evaluate differences in the depth of focus after implantation of a spherical or aspheric IOL in hypermetropic and emmetropic patients. After implantation of...

Evaluation of Nano-crystalline Hydroxyapatite Silica Gel in Management of Periodontal Intrabony Defects

A clinical and radiographic evaluation of Nano-crystalline hydroxyapatite silica gel in comparison with bone allograft and open flap debridement for management of periodontal intrabony def...

Medical and Biotech [MESH] Definitions

The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary.

A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.

Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.

Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.

An assessment of HEALTH STATUS requested by third parties (e.g. insurers, adjudicating bodies, law enforcement, attorneys, etc) on a subject’s functional ability. Such information may be used in optimizing treatment or making informed decisions on compensation.

Quick Search

DeepDyve research library

Relevant Topics

Drug Delivery
<!--LGfEGNT2Lhm-->Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  <!--LGfEGNT2Lhm-->Drug delivery technologies are <!--LGfEGNT2Lhm-->patent pr...

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Searches Linking to this Article