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Exploratory Assessment Of Oxygen Flow Assisted Cutaneous Administration Of Methotrexate For Superficial Basal Cell Carcinoma, Mycosis Fungoides And Extramammary Paget's Disease.

08:00 EDT 9th September 2019 | BioPortfolio

Summary of "Exploratory Assessment Of Oxygen Flow Assisted Cutaneous Administration Of Methotrexate For Superficial Basal Cell Carcinoma, Mycosis Fungoides And Extramammary Paget's Disease."

The molecular weight of methotrexate (MTX) makes cutaneous penetration difficult. Oxygen flow could enhance the skin permeation of MTX diluted in the LP3 carrier system. This pilot study aims to assess the efficacy, safety and tolerance of oxygen-flow-administered (OFA)-LP3-MTX3% for treating superficial skin cancers. Patients with superficial basal cell carcinoma (sBCC)(n=12), extramammary Paget's disease (EMPD)(n=5), mycosis fungoides classic type (CMF) (n=10) and folliculotropic (FMF) (n=6) were included in the study and were treated with 4 weekly applications of OFA-LP3-MTX3%. Photographs and biopsies were performed before (T0) and one month after treatment (T1). At T1, the mean sBCC ECT and EMPD EOSP clinical scores, and the modified CAILS CMF and FMF scores were improved by 77.5±17.1% (p<0.0001), 66.7±22.9% (p=0,011), 51.3±32.2% (p=0.0007) and 27.8±32.0% (p=0.086), respectively. At T1, histology revealed partial and total clearances for sBCC (1/12, 11/12), EMPD (4/5,1/5), CMF (8/10, 2/10) and FMC (6/6, 0/6), respectively. Tolerance was excellent and no pain was observed. MTX was never detectable in serum at baseline and 1, 2, 3, 8, 24, 48- and 72-hours post-treatment. In conclusion, the interesting therapeutic efficacy of OFA-LP3-MTX3% for treating sBCC, EMPD and MF lesions incites to further studies at larger scale.

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Name: The Journal of investigative dermatology
ISSN: 1523-1747
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