Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells.

08:00 EDT 9th September 2019 | BioPortfolio

Summary of "Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells."

T-regulatory (Treg) cells suppress the immune response to maintain homeostasis. There are 2 main subsets of Treg cells: FOXP3-positive Treg cells, which do not produce high levels of effector cytokines, and type 1 Treg (Tr1) cells, which are FOXP3-negative and secrete interleukin 10 (IL10). IL10 is an anti-inflammatory cytokine, so Tr1 cells might be used in treatment of inflammatory bowel diseases. We aimed to develop methods to isolate and expand human Tr1 cells and define their functions.


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This article was published in the following journal.

Name: Gastroenterology
ISSN: 1528-0012


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