Topics

A Metamodeling Approach for Instant Severity Assessment and Uncertainty Quantification of Iliac Artery Stenoses.

08:00 EDT 1st August 2019 | BioPortfolio

Summary of "A Metamodeling Approach for Instant Severity Assessment and Uncertainty Quantification of Iliac Artery Stenoses."

Complex models of blood flow in stenosed arteries can be used to patient-specifically predict outcome metrics, thereby supporting the physicians in decision making processes. However, these models are time consuming which limits the feasibility of output uncertainty quantification. Accurate surrogates (metamodels) might be the solution. In this study, we aim to demonstrate the feasibility of a generalized polynomial chaos expansion (gPCE)-based metamodel to predict a clinically relevant output metric and to quantify output uncertainty. As an example, a metamodel was constructed from a 2D CFD model that was shown to be able to estimate translesional pressure drops in iliac artery stenoses (-0.9±12.7mmHg, R2=0.81). The metamodel was constructed from a virtual database using the adaptive gPCE method. The constructed metamodel was then applied to 25 stenosed iliac arteries to predict the patient-specific pressure drop and to perform uncertainty quantification. Comparing predicted pressure drops of the metamodel and in vivo measured pressure drops, the mean bias (-0.2±13.7mmHg) and the coefficient of determination (R2=0.80) were as good as of the original 2D model. Uncertainty quantification results of the 2D and metamodel were comparable. Estimation of the uncertainty interval using the original 2D model took 14 days, whereas the result of the metamodel was instantly available. In conclusion, it is feasible to quantify the uncertainty of the output metric and perform sensitivity analysis instantly using a metamodel. Future studies should investigate the possibility to construct a metamodel of more complex problems.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of biomechanical engineering
ISSN: 1528-8951
Pages:

Links

DeepDyve research library

PubMed Articles [16335 Associated PubMed Articles listed on BioPortfolio]

Direct Comparison between Bayesian and Frequentist Uncertainty Quantification for Nuclear Reactions.

Until recently, uncertainty quantification in low energy nuclear theory was typically performed using frequentist approaches. However in the last few years, the field has shifted toward Bayesian stati...

Tailor-made iliac branched device for preserving the internal iliac artery in patients with common iliac artery aneurysm.

Endovascular repair with stent-graft is a treatment option for patient with common iliac artery aneurysm (CIAA). However, the preservation of the internal iliac artery is a concern. The commercially a...

Measurement accuracy and uncertainty in plant biomechanics.

All scientific measurements are affected to some degree by both systematic and random errors. The quantification of these errors supports correct interpretation of data, thus supporting scientific pro...

Confronting variability with uncertainty in the ecotoxicological impact assessment of down-the-drain products.

The use of down-the-drain products and the resultant release of chemicals may lead to pressures on the freshwater environment. Ecotoxicological impact assessment is a commonly used approach to assess ...

Endovascular Repair of Iliac Artery Aneurysms: A Single Center Experience in 10-Years.

Isolated iliac artery aneurysms (IAAs) are rare, but nonetheless life-threatening when ruptured. The endovascular approach has taken over open repairs in time. The reported data is constituted of a re...

Clinical Trials [7231 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Peri-surgical Results at Short and Mean Terms of the GORE ® Excluder Iliac Branch Endoprosthesis

The aim of this project is to demonstrate the benefit of the use of aortic iliac branch endoprosthesis in the iliac aneurysms and to avoid the classic complications.

Prospective Multicenter Study for the Endovascular Treatment of Iliac Aneurysm With the Branched E-liac Stent Graft

In this study, patients will be observed who receive an E-liac Stent Graft for treatment of isolated iliac aneurysms or an E-liac Stent Graft in combination with an E-tegra Stent Graft for...

Registry in Patients With Aorto-iliac or Iliac Aneurysms

The PLIANT II registry is undertaken to examine the real-world outcome after treatment of consecutive patients with uni- or bilateral aorto-iliac or iliac aneurysms using the E-liac Stent ...

Endovascular Treatment of Aorto-iliac Occlusions

This study compares early and long-term results of the endovascular treatment among patients with different types of aorto-iliac occlusions.

Computerized Cognitive Bias Intervention for Intolerance of Uncertainty

This investigation examines the efficacy of a brief, one-session computerized interpretation bias modification paradigm (CBM-I) in the reduction of intolerance of uncertainty. Intolerance ...

Medical and Biotech [MESH] Definitions

Abnormal balloon- or sac-like dilatation in the wall of any one of the iliac arteries including the common, the internal, or the external ILIAC ARTERY.

An assessment of a patient's illness, its chronicity, severity, and other qualitative aspects.

A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation.

A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.

CONNECTIVE TISSUE of the anterior compartment of the THIGH that has its origins on the anterior aspect of the iliac crest and anterior superior iliac spine, and its insertion point on the iliotibial tract. It plays a role in medial rotation of the THIGH, steadying the trunk, and in KNEE extension.

Quick Search


DeepDyve research library

Searches Linking to this Article