A Metamodeling Approach for Instant Severity Assessment and Uncertainty Quantification of Iliac Artery Stenoses.

08:00 EDT 1st August 2019 | BioPortfolio

Summary of "A Metamodeling Approach for Instant Severity Assessment and Uncertainty Quantification of Iliac Artery Stenoses."

Complex models of blood flow in stenosed arteries can be used to patient-specifically predict outcome metrics, thereby supporting the physicians in decision making processes. However, these models are time consuming which limits the feasibility of output uncertainty quantification. Accurate surrogates (metamodels) might be the solution. In this study, we aim to demonstrate the feasibility of a generalized polynomial chaos expansion (gPCE)-based metamodel to predict a clinically relevant output metric and to quantify output uncertainty. As an example, a metamodel was constructed from a 2D CFD model that was shown to be able to estimate translesional pressure drops in iliac artery stenoses (-0.9±12.7mmHg, R2=0.81). The metamodel was constructed from a virtual database using the adaptive gPCE method. The constructed metamodel was then applied to 25 stenosed iliac arteries to predict the patient-specific pressure drop and to perform uncertainty quantification. Comparing predicted pressure drops of the metamodel and in vivo measured pressure drops, the mean bias (-0.2±13.7mmHg) and the coefficient of determination (R2=0.80) were as good as of the original 2D model. Uncertainty quantification results of the 2D and metamodel were comparable. Estimation of the uncertainty interval using the original 2D model took 14 days, whereas the result of the metamodel was instantly available. In conclusion, it is feasible to quantify the uncertainty of the output metric and perform sensitivity analysis instantly using a metamodel. Future studies should investigate the possibility to construct a metamodel of more complex problems.


Journal Details

This article was published in the following journal.

Name: Journal of biomechanical engineering
ISSN: 1528-8951


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Medical and Biotech [MESH] Definitions

Abnormal balloon- or sac-like dilatation in the wall of any one of the iliac arteries including the common, the internal, or the external ILIAC ARTERY.

An assessment of a patient's illness, its chronicity, severity, and other qualitative aspects.

A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation.

A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.

CONNECTIVE TISSUE of the anterior compartment of the THIGH that has its origins on the anterior aspect of the iliac crest and anterior superior iliac spine, and its insertion point on the iliotibial tract. It plays a role in medial rotation of the THIGH, steadying the trunk, and in KNEE extension.

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