Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Pregnancy does not adversely impact diagnostic tests for HTLV-1/2 infection."

Mother-to-child-transmission (MTCT) of human T-cell lymphotropic virus type-1(HTLV-1) contributes disproportionately to the burden of HTLV-1 associated diseases. All preventive measures to avoid MTCT rely on the identification of infected mothers. However, the impact of pregnancy on HTLV-1 diagnosis has not been clearly assessed. Paired samples from 21 HTLV-1 infected women taken during pregnancy and while not pregnant were analysed by CMIA and PCR. The signal-to-cut-off values (S/CO) were higher during pregnancy than in the paired non-pregnant samples. HTLV-1 proviral load did not alter significantly by pregnant state. S/CO positively correlated with HTLV proviral load. Pregnancy does not impair the diagnosis of HTLV-1/2, by either immunological (CMIA) or molecular (qPCR/nPCR) tests.


Journal Details

This article was published in the following journal.

Name: PLoS neglected tropical diseases
ISSN: 1935-2735
Pages: e0007736


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Medical and Biotech [MESH] Definitions

Diagnostic procedures, such as laboratory tests and x-rays, routinely performed on all individuals or specified categories of individuals in a specified situation, e.g., patients being admitted to the hospital. These include routine tests administered to neonates.

The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.

Tests to determine whether or not an individual is pregnant.

Methods of detecting pregnancy by examining the levels of human chorionic gonadotropin (HCG) in plasma or urine.

Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.

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