Topics

Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics."

Circadian rhythms are generated by interlocked transcriptional-translational negative feedback loops (TTFLs), the molecular process implemented within a cell. The contributions, weighting and balancing between the multiple feedback loops remain debated. Dissociated, free-running dynamics in the expression of distinct clock genes has been described in recent experimental studies that applied various perturbations such as slice preparations, light pulses, jet-lag, and culture medium exchange. In this paper, we provide evidence that this "presumably transient" dissociation of circadian gene expression oscillations may occur at the single-cell level. Conceptual and detailed mechanistic mathematical modeling suggests that such dissociation is due to a weak interaction between multiple feedback loops present within a single cell. The dissociable loops provide insights into underlying mechanisms and general design principles of the molecular circadian clock.

Affiliation

Journal Details

This article was published in the following journal.

Name: PLoS computational biology
ISSN: 1553-7358
Pages: e1007330

Links

DeepDyve research library

PubMed Articles [7220 Associated PubMed Articles listed on BioPortfolio]

Synthesis of the Dynamical Properties of Feedback Loops in Bio-pathways.

Feedback loops regulate various biological functions such as oscillations, bistability and robustness. They play a significant role in developmental signalling and failure of feedback can lead to dise...

Soma-axon coupling configurations that enhance neuronal coincidence detection.

Coincidence detector neurons transmit timing information by responding preferentially to concurrent synaptic inputs. Principal cells of the medial superior olive (MSO) in the mammalian auditory brains...

The Size-Dependent Formation of an Ion Pair in HSO-(HO) : A Molecular Model for Probing the Micro-Solvation of Acid Dissociation.

With a pKa of 2.0, HSO4- is not a strong acid, as its dissociation percentage is only ~10% in a solution of 1 M. However, our ab initio molecular dynamics and density functional theory calculations sh...

Loop analysis of blood pressure/volume homeostasis.

We performed a mathematical analysis of the dynamic control loops regulating the vasomotor tone of vascular smooth muscle, blood volume, and mean arterial pressure, which involve the arginine vasopres...

Deaf readers benefit from lexical feedback during orthographic processing.

It has been proposed that poor reading abilities in deaf readers might be related to weak connections between the orthographic and lexical-semantic levels of processing. Here we used event related pot...

Clinical Trials [1617 Associated Clinical Trials listed on BioPortfolio]

Dissociation Investigation Study in Sex Offenders

Background: Adverse childhood experience have been described in sexual offenders but the link with the offence need to be further investigated. Investigators postulate that one of the clin...

Unilateral Lumbopelvic Fixation for Spinopelvic Dissociation in Skin Compromise

Lumbopelvic fixation is the treatment opation for spinopelvic dissociation. In our study we will compare unilateral versus bilateral lumbopelvic fixation as regarding post operative pain a...

Pathophysiology of Neuronal Oscillations Within Subthalamo-cortical Loops in Parkinson's Disease

Neuronal activity in circuits between the basal ganglia (BG) and motor cortical areas is abnormally synchronised and rhythmic. The oscillatory activity prevails at 8-30 Hz in untreated Par...

Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients

Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.

Torsionally Adaptive Prosthesis for Individuals With Lower Limb Amputation

When prescribing a prosthetic foot, clinicians face a dizzying array of choices as more than 200 different prosthetic feet are available. While these conventional prosthetic feet primarily...

Medical and Biotech [MESH] Definitions

A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.

A sub-family of smad proteins that inhibit cell signaling by RECEPTOR-REGULATED SMAD PROTEINS. They form autoinhibitory feedback loops in the TGF-BETA signaling pathway and mediate signaling cross-talk with other signaling pathways

Intracellular signaling adaptor proteins that play a role in the coupling of SYNDECANS to CYTOSKELETAL PROTEINS.

Protein factors that inhibit the dissociation of GDP from GTP-BINDING PROTEINS.

An abundantly-expressed rho GDP-dissociation inhibitor subtype that regulates a broad variety of RHO GTPASES.

Quick Search


DeepDyve research library

Relevant Topics

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Gene Expression
The process of gene expression is used by eukaryotes, prokaryotes, and viruses to generate the macromolecular machinery for life. Steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-tran...


Searches Linking to this Article