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In pharmaceutical compounding, strict adherence to a protocol for hand hygiene and glove sanitizing is essential to ensure the purity, safety, and effectiveness of sterile preparations; reduce patient morbidity and mortality; and decrease the cost of health care. Alcohols and chlorhexidine gluconate are among the most effective bactericides, virucides, and fungicides, and acquired resistance to those agents has not been shown in clinical practice. This article, which is part 1 in a series of 2, pertains primarily to alcohol-based hand rubs that are appropriate for use in sterile compounding (glove sanitizing is discussed as part of the handsanitizing process). In a brief overview of those products, we define pertinent terminology, examine the necessity of and requirements for the use of sanitizers, review their mechanism of action and composition, consider factors pertinent to their selection, and present a protocol for their application. In part 2 of this series, the topics examined include a comparison of various alcohol-based sanitizers and answers to compounders' frequently asked questions about their use.
This article was published in the following journal.
Name: International journal of pharmaceutical compounding
This 2-part series discusses quality-control and quality-assurance issues along with physical and chemical analytical methods and microbiological testing related to both sterile and nonsterile compoun...
The July-August 2019 issue of the International Journal of Pharmaceutical Compounding includes part 1 of a 3-part article on the topic of excipients used in nonsterile compounding. This article, which...
Quality control (QC) can be viewed as a diagnostic test that is used to determine whether an assay is in statistical control. Using this framework, QC performance can be evaluated using familiar metri...
Quality control (QC) policies are usually designed using power curves. This type of analysis reasons from a cause (a shift in the assay results) to an effect (a signal from the QC monitoring process)....
The processing power in commercially available hand-held devices has improved dramatically in recent years. In parallel, techniques used in high frame-rate medical ultrasound imaging, specifically pla...
The necessity of Hand hygiene (HH) before donning non-sterile gloves is unknown. Furthermore, because of the additional time required to cleanse hands and then don gloves, as well as the c...
The Virtual Reality Glove for Hand and Arm Rehabilitation (vREHAB) trial is a randomized, controlled, phase 3 trial aiming to evaluate the safety, usability, and efficacy of a virtual real...
This research aims to integrate and develop a novel Brain-Computer Interface (BCI) controlled soft robotic glove, evaluate the ability of the glove in achieving common hand grasping postur...
The implementation of early sensory re-education (SR) techniques, aimed to preserve the cortical hand area, such as the use of audio-tactile interaction, becomes an important strategy to o...
Epidermolysis Bullosa (EB) is a group of genetic conditions causing extensive, painful skin blisters and wounds. Four main types of EB are recognised, which all affect the hands but those ...
Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
A putative protein interaction module, approximately 70 amino acids long, that forms a small five-helix bundle with two large interfaces which may homo- and hetero-oligomerize, or bind non-sterile-alpha motif targets. The sterile alpha motif is present in a wide variety of eukaryotic proteins that function in diverse biological processes.
Membrane-associated calcium-binding proteins that are characterized by N-terminal EF HAND MOTIFS and a STERILE ALPHA MOTIF. They function as sensors of ENDOPLASMIC RETICULUM calcium levels and translocate from the ER to the plasma membrane to activate CALCIUM CHANNELS in response to intracellular calcium depletion.
Automatic or hand operated equipment used to control and extinguish fires.
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...