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Antifibrinolytic Therapy in Surgery for Adolescent Idiopathic Scoliosis Does the Level 1 Evidence Translate to Practice?

08:00 EDT 1st September 2018 | BioPortfolio

Summary of "Antifibrinolytic Therapy in Surgery for Adolescent Idiopathic Scoliosis Does the Level 1 Evidence Translate to Practice?"

Previous randomized controlled trials have demonstrated the efficacy of antifibrinolytic agents in the reduction of intraoperative blood loss in adolescent idiopathic scoliosis (AIS) surgery. Tranexamic acid (TXA) was found to be more effective at reducing total blood loss compared with epsilon-aminocaproic acid (AM) than placebo. We set out to study whether or not the level 1 evidence can be corroborated in a large multicenter, multisurgeon cohort.

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This article was published in the following journal.

Name: Bulletin of the Hospital for Joint Disease (2013)
ISSN: 2328-5273
Pages: 165-170

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Medical and Biotech [MESH] Definitions

Treatment using irradiation with LASER light of low power intensity so that the effects are not due to heat, as in LASER THERAPY. These non-thermal effects are thought to be mediated by a photochemical reaction that alters CELL MEMBRANE PERMEABILITY, leading to increased mRNA synthesis and CELL PROLIFERATION. Low-level laser therapy has been used for a wide variety of conditions, but most frequently for wound healing and pain control.

A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

A followup operation to examine the outcome of the previous surgery and other treatments, such as chemotherapy or radiation therapy.

Any observable response or action of an adolescent.

An adolescent who is receiving long-term in-patient services or who resides in an institutional setting.

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