Patient-Specific Modeling of Aerosol Delivery in Healthy and Asthmatic Adults.

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Summary of "Patient-Specific Modeling of Aerosol Delivery in Healthy and Asthmatic Adults."

The magnitude and regional heterogeneity of airway obstructions in severe asthmatics is likely linked to insufficient drug delivery, as evidenced by the inability to mitigate exacerbations with inhaled aerosol medications. To understand the correlation between morphometric features, airflow distribution, and inhaled dosimetry, we perform dynamic computational simulations in two healthy and four asthmatic subjects. Models incorporate CT-based and patient-specific central airway geometries and hyperpolarized (HP) He MRI measured segmental ventilation defect percentages (SVDP), implemented as resistance boundary conditions. Particles (diameters, d = 1, 3, and 5 µm) are simulated throughout inhalation and we record their initial conditions, both spatially and temporally, with their fate in the lung. Predictions highlight that total central airway deposition is the same between the healthy subjects (26.6%, d = 3 µm), but variable between the asthmatic subjects (ranging from 5.9% to 59.3%, d = 3 µm). We found that by preferentially releasing the particles during times of fast or slow inhalation rates, we either enhance central airway deposition percentages or peripheral particle delivery, respectively. These predictions highlight the potential to identify patients that may not receive adequate therapeutic dosages with inhaled aerosol medication, with simulations, and therefore identify patients which may benefit from alternative treatment strategies. Further, by improving regional dose levels, we may be able to preferentially deliver drugs to the airways in need, reducing associated adverse side effects.


Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601


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