Vestibulo-sympathetic reflex in patients with bilateral vestibular loss.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Vestibulo-sympathetic reflex in patients with bilateral vestibular loss."

This study assessed cardiovascular control during Head‑Down Neck Flexion (HDNF) in a group of patients suffering from total bilateral idiopathic vestibular loss (BVL) for 7 ± 2 years. Nine adult patients (age 54 ± 6 years) with BVL were recruited. Calf blood flow (CBF), mean arterial pressure (MAP), heart rate (HR) were measured with eyes closed in two lying body positions: ventral prone (VP) and lateral (LP) on the left side. Vascular resistance (CVR) was calculated as MAP/CBF. The HDNF protocol consisted in passively changing the head position: head up (HU) ‑ head down (HD) ‑ HU. Measurements were taken twice at each head position. In ventral position CBF significantly decreased in the HD 3.65 ± 0.65 mL.min.100mL vs HU 4.64 ± 0.71; p < 0.002, while the CVR in the VP significantly raised in the HD 31.87 ± 6.93 arbitrary units vs 25.61 ± 6.36 in HU; p < 0.01. In the LP no change in CBF or CVR was found between the two head positions. MAP and HR presented no difference between HU and HD in both body positions. Age of patients did not significantly affect the results. Decrease in CBF of the BVL patients was similar to the decrease observed with the same HDNF protocol in normal subjects. This suggests a sensory compensation for the lost vestibular inputs that could originate from the integration of inputs from trunk graviceptors, proprioceptive and cutaneous receptors. Another possibility is that HDNF vascular effect is evoked mostly by non-labyrinthine sensors.


Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601


DeepDyve research library

PubMed Articles [29239 Associated PubMed Articles listed on BioPortfolio]

Changes in gain of horizontal vestibulo-ocular reflex during spaceflight.

The vestibulo-ocular reflex (VOR) is a basic function of the vestibular system that stabilizes gaze during head movement. Investigations on how spaceflight affects VOR gain and phase are few, and the ...

Impact of Bilateral Vestibulopathy on Spatial and Nonspatial Cognition: A Systematic Review.

Hearing loss is considered an independent risk factor for dementia. Growing evidence in animal and human studies suggest that not only hearing loss but also vestibular loss might result in cognitive d...

Endre Hőgyes (1847-1906), Forgotten Father of the Vestibulo-Ocular Reflex.

Throughout the history of vestibular research, the discovery of the vestibulo-ocular reflex in 1881 by Endre Hőgyes (1847-1906) is rarely mentioned. The aim of this study is to review Hőgyes' vestib...

Video-head impulse test results in patients with Menière's disease related to duration and stage of disease.

The video-head impulse test employs the vestibulo-ocular reflex (VOR) to assess vestibular function. To this day, no consensus has been reached among scientists in terms of whether or not vHIT results...

Non-Human Primate Vestibulo-Ocular Reflex Responses to Prosthetic Vestibular Stimulation are Robust to Pulse Timing Errors Caused by Temporal Discretization.

Electrical stimulation of vestibular afferent neurons to partially restore semicircular canal sensation of head rotation and the stabilizing reflexes that sensation supports has potential to effective...

Clinical Trials [4799 Associated Clinical Trials listed on BioPortfolio]

Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation

The objective for this study is to compare outcome measures from vestibular rehabilitation (VPT) delivered in a traditional method against a new device Incremental Velocity Error (IVE) tha...


Falls in the elderly population are a major public health problem because of their frequency and their consequences, notably in terms of dependence their cost to society. In most cases, ba...

Hearing Loss, Vestibular Loss and Cognitive Performance

Hearing loss is an established independent risk factor for dementia. Likewise, recent research demonstrated cognitive deficits in subjects with vestibular loss. However, in these studies d...

Three-dimensional Virtual Reality Procedures in Vestibular Rehabilitation

The aim of the present study will be to discover possible (i) improvements achievable in unilateral vestibular hypofunction patients using a self-assessed head-mounted device (HMD)-based g...

Multichannel Vestibular Implant Early Feasibility Study

Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no adequately effective treatment for individuals suffering chronic imbala...

Medical and Biotech [MESH] Definitions

A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS.

A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)

Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.

Hearing loss due to disease of the AUDITORY PATHWAYS (in the CENTRAL NERVOUS SYSTEM) which originate in the COCHLEAR NUCLEI of the PONS and then ascend bilaterally to the MIDBRAIN, the THALAMUS, and then the AUDITORY CORTEX in the TEMPORAL LOBE. Bilateral lesions of the auditory pathways are usually required to cause central hearing loss. Cortical deafness refers to loss of hearing due to bilateral auditory cortex lesions. Unilateral BRAIN STEM lesions involving the cochlear nuclei may result in unilateral hearing loss.

The vestibular part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The vestibular nerve fibers arise from neurons of Scarpa's ganglion and project peripherally to vestibular hair cells and centrally to the VESTIBULAR NUCLEI of the BRAIN STEM. These fibers mediate the sense of balance and head position.

Quick Search

DeepDyve research library

Relevant Topic

Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Searches Linking to this Article