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Chemodivergent and Stereoselective Construction of -Difluoroallylic Amines from Masked Difluorodiazo Reagents.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Chemodivergent and Stereoselective Construction of -Difluoroallylic Amines from Masked Difluorodiazo Reagents."

We report a general and efficient approach to construct achiral and chiral -difluoroallylic amines from a masked difluorodiazo reagent (PhSOCFCHN) and readily available imines. This facile protocol takes advantage of the phenylsulfonyl and diazo moieties as efficient activating and directing groups to assist difluoroalkyl incorporation and facilitate the chemodivergent and stereoselective formation of -difluoroallylic amines.

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Name: Organic letters
ISSN: 1523-7052
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