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Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of and Their Cytotoxicity.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of and Their Cytotoxicity."

Two octahydro-protoberberine alkaloids, alangiifoliumines A () and B (), and two new protoemetine derivatives, alangiifoliumines C () and D (), together with 11 known compounds, have been isolated from the stems of . While the structures of these compounds were elucidated by spectroscopic methods, the absolute configurations of the new alkaloids were determined by conformational analysis and time-dependent density functional theory-electronic circular dichroism spectra calculations on selected stereoisomers. Compounds and represent the first 5,8,8a,9,12,12a,13,13a-octahydro-protoberberine derivatives, in which the aromatic ring D was reduced to cyclohexene. All the compounds isolated were evaluated for their cytotoxic activity against three human cancer cell lines: A-549, HeLa, and SKOV-3. Alkaloids , , and - exhibited inhibitory effects against all three human cancer cell lines, with half-maximal inhibitory concentration (IC) values in the range of 3 nM to 9.4 μM.

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This article was published in the following journal.

Name: Journal of natural products
ISSN: 1520-6025
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