DNA-Inspired Adhesive Hydrogels Based on the Biodegradable Polyphosphoesters Tackified by Nucleobase.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "DNA-Inspired Adhesive Hydrogels Based on the Biodegradable Polyphosphoesters Tackified by Nucleobase."

Since adhesive hydrogels showed wide applications ranging from wearable soft materials to medical sealant, more and more attentions have been paid on exploration of novel adhesive hydrogels. However, the un-easily removed residue caused by the excessive adhesive strength and sluggish degradation or non-degradation behaviors of the adhesive have always been challenges. Inspired from the multiple complementary hydrogen bonds interactions in DNA, the bio-inspired nucleobase (A, T and U) monomers were firstly synthesized, and used to tackify polyphosphoester hydrogels. The multiple hydrogen bonds and hydrophobic interactions between purine rings and pyrimidine functionalities endowed the hydrogels with excellent controllable adhesive properties. Besides of this, it has been found that these nucleobase tackified hydrogels could be easily peeled off with no residue left, and could be totally degraded under the alkaline condition due to the hydrolysis of phosphoester chains. At the same time, they also exhibited controllable biodegradation to different extent under the different pH conditions. The excellent adhesive performance, controllable biodegradation, and excellent biocompatibility showed by this nucleobase tackified polyphosphoester adhesive hydrogel demonstrated its great potential in wound dressing, tissue sealant and so on.


Journal Details

This article was published in the following journal.

Name: Biomacromolecules
ISSN: 1526-4602


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Medical and Biotech [MESH] Definitions

A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.

Organic polymeric materials which can be broken down by naturally occurring processes. This includes plastics created from bio-based or petrochemical-based materials.

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