A dynamic titania nanotubes surface achieves UV-triggered charge-reversal and enhances cell differentiation.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "A dynamic titania nanotubes surface achieves UV-triggered charge-reversal and enhances cell differentiation."

Stimuli-responsive biomaterials supply a promising solution to adapt to complex physiological environment for different biomedical applications. In this study, a dynamic UV-triggered pH responsive biosurface was constructed on titania nanotubes (TNTs) by loading photoacid generators, diphenyliodonium chloride (DPIC), into the nanotubes, and grafting 2,3-dimethyl maleic anhydride (DMMA)-modified hyperbranched poly(L-lysine) (HBPLL) onto the surface. The local acidity was dramatically enhanced by UV irradiation for only 30 s, leading to the dissociation of DMMA and thereby the transformation of surface chemistry from negatively charged caboxyl groups to positively charged amino groups. The TNTs-HBPLL-DMMA substrate could better promote proliferation and spreading of rat bone mesenchymal stem cells (rBMSCs) after UV-irradiation. The osteogenic differentiation of rBMSCs was enhanced due to the charge reversal in combination with the titania-based substrates.


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This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252


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Medical and Biotech [MESH] Definitions

NANOTUBES formed from cyclic peptides (PEPTIDES, CYCLIC). Alternating D and L linkages create planar rings that self assemble by stacking into nanotubes. They can form pores through CELL MEMBRANE causing damage to cells.

An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.

Nanometer-sized tubes composed of various substances including carbon (CARBON NANOTUBES), boron nitride, or nickel vanadate.

Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.

A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.

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