Track topics on Twitter Track topics that are important to you
The nature and specificity of the self-antigens targeted by autoantibodies characteristic of systemic autoimmune diseases can suggest clues to mechanisms initiating disease. In systemic lupus erythematosus (SLE), anti-double stranded DNA autoantibodies are features of active disease and are particularly associated with lupus nephritis, and the identity of the self or foreign antigens that "break tolerance", leading to anti-dsDNA and other autoantibody specificities, has been a topic of extensive study. In that context, the studies published by Carter et al (1) identifying reactivity of sera from SLE patients with the 40 kD protein product of the first open-reading frame (ORF) of the human LINE-1 (L1) retroelement are of great interest. This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Arthritis & rheumatology (Hoboken, N.J.)
We are delighted that our discovery of autoantibodies directed against LINE-1 retroelement-encoded p40/ORF1p in SLE patients (1) has been so rapidly replicated and we thank Dr. Crow for her excellent ...
Reactive oxygen species (ROS), such as the superoxide anion, the hydroxyl radical and singlet oxygen, can influence cellular processes in many ways. However, the molecular mechanisms of ROS action in ...
Expansion of the genetic code with unnatural amino acids (Uaas) has significantly increased the chemical space available to proteins for exploitation. Due to the inherent limitation of translational m...
This study aimed to investigate the association between cumulative C-reactive protein (cumCPR) and arterial stiffness.
C-reactive protein (CRP) is used to assist the diagnosis and monitoring of newborn infection. Little is known about CRP activity after birth in the absence of infection.
The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant.
A prospective study of 40 patients admitted with the diagnosis of enterocutaneous fistula and prepared for definite surgical repair in the form of resection anastomosis of ECF. The investi...
The judicious use of antibiotics is one of the main measures to limit the emergence of multidrug-resistant pathogen related to excessive antimicrobial use. A recent study demonstrated that...
To examine the independent association of serum total homocysteine and C-reactive protein with arteriosclerotic cardiovascular disease morbidity and mortality.
The main objective of this clinical study is to determine the normal reference range of the Nanōmix eLab® (eLab) C-Reactive Protein, Procalcitonin and Lactate Assay, whereby collected bl...
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored cell surface receptors that are specific for GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS. They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein.
A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.
Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Autoimmune disorders are conditions that occurs when the immune system mistakenly attacks and destroys healthy body tissue. There are more than 80 different types of autoimmune disorders. Normally the immune system's white blood cells help protect ...
Lupus is a complex and poorly understood condition that affects many parts of the body and causes symptoms ranging from mild to life-threatening. There are several types of lupus. The main types are: discoid lupus erythematosus drug-induced lu...