IgG reactive with the p40 protein encoded by the LINE-1 retroelement.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "IgG reactive with the p40 protein encoded by the LINE-1 retroelement."

The nature and specificity of the self-antigens targeted by autoantibodies characteristic of systemic autoimmune diseases can suggest clues to mechanisms initiating disease. In systemic lupus erythematosus (SLE), anti-double stranded DNA autoantibodies are features of active disease and are particularly associated with lupus nephritis, and the identity of the self or foreign antigens that "break tolerance", leading to anti-dsDNA and other autoantibody specificities, has been a topic of extensive study. In that context, the studies published by Carter et al (1) identifying reactivity of sera from SLE patients with the 40 kD protein product of the first open-reading frame (ORF) of the human LINE-1 (L1) retroelement are of great interest. This article is protected by copyright. All rights reserved.


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This article was published in the following journal.

Name: Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205


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Medical and Biotech [MESH] Definitions

A plasma protein that circulates in increased amounts during inflammation and after tissue damage.

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