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IgG reactive with the p40 protein encoded by the LINE-1 retroelement.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "IgG reactive with the p40 protein encoded by the LINE-1 retroelement."

The nature and specificity of the self-antigens targeted by autoantibodies characteristic of systemic autoimmune diseases can suggest clues to mechanisms initiating disease. In systemic lupus erythematosus (SLE), anti-double stranded DNA autoantibodies are features of active disease and are particularly associated with lupus nephritis, and the identity of the self or foreign antigens that "break tolerance", leading to anti-dsDNA and other autoantibody specificities, has been a topic of extensive study. In that context, the studies published by Carter et al (1) identifying reactivity of sera from SLE patients with the 40 kD protein product of the first open-reading frame (ORF) of the human LINE-1 (L1) retroelement are of great interest. This article is protected by copyright. All rights reserved.

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Name: Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
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Medical and Biotech [MESH] Definitions

A plasma protein that circulates in increased amounts during inflammation and after tissue damage.

A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored cell surface receptors that are specific for GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS. They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein.

A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.

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Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.

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