Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Up-regulating miR-141-3p.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Up-regulating miR-141-3p."

Alpinumisoflavone (AIF) as principal active ingredient of traditional Chinese herb Derris eriocarpa exerts a broad spectrum of anti-cancer activities against solid tumors. However, little is known about the effect of AIF on Papillary Thyroid Cancer (PTC). Objectives of this study are to investigate the effect of AIF on cell growth, apoptosis, and metastasis of PTC cells and uncover its underlying mechanisms. Results showed that AIF treatment notably suppressed cell viability, migration, invasion, and epithelial-mesenchymal transition (EMT) process, as well as induced apoptotic cell death. In addition, microarray analysis results revealed that miR-141-3p level was dramatically elevated upon AIF insultation, suggesting that miR-141-3p may mediate the suppressive role of AIF against PTC. Moreover, miR-141-3p knockdown effectively reversed the effects of AIF on cell growth, migration, invasion and EMT, while promoted PTC cells apoptosis escape. Furthermore, in vivo findings also confirmed that the anti-growth and anti-metastasis activities of AIF were, at least partly, mediated by up-regulation of miR-141-3p. Overall, AIF could serve as a potential anti-cancer compound for PTC treatment. This article is protected by copyright. All rights reserved.


Journal Details

This article was published in the following journal.

Name: Anatomical record (Hoboken, N.J. : 2007)
ISSN: 1932-8494


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