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Beyond the Corey-Chaykovsky Reaction: Synthesis of Unusual Cyclopropanoids via Desymmetrization and Thereof.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Beyond the Corey-Chaykovsky Reaction: Synthesis of Unusual Cyclopropanoids via Desymmetrization and Thereof."

New desymmetrization-based protocols for the synthesis of highly functionalized indeno-spirocyclopropanes and cyclopropa-fused indanes have been established through the unexpected reactions triggered by the Corey-Chaykovsky reagent. These structures were further elaborated in one-step to privileged scaffolds such as fluorenones, indenones, and naphthaphenones. For instance, an acid-catalyzed transformation of indeno-spirocyclopropanes provided fluorenones via a homo-Nazarov-type cyclization, and naphthaphenones were obtained via an acid-catalyzed cyclopropane ring-opening/retro-Michael sequence.

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Name: Chemistry, an Asian journal
ISSN: 1861-471X
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