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CD80 expression and infiltrating regulatory T cells in idiopathic nephrotic syndrome of childhood.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "CD80 expression and infiltrating regulatory T cells in idiopathic nephrotic syndrome of childhood."

CD80 (also known as B7-1) is a costimulatory molecule and was reported to be expressed in biopsies and also excreted in urine from patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). CD80 is inhibited by CTLA4, which is mainly expressed on regulatory T cells (Tregs). Ineffective circulating Treg response was accused in pathogenesis of nephrotic syndrome. In this study, we aimed to evaluate CD80 expression and infiltrating Tregs in children with MCD and FSGS.

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Name: Pediatrics international : official journal of the Japan Pediatric Society
ISSN: 1442-200X
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