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Enhancement of Bactericidal Activity via Cyclic Poly(cationic liquid) Brushes.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "Enhancement of Bactericidal Activity via Cyclic Poly(cationic liquid) Brushes."

In addition to extensive studies of conventional linear poly(ionic liquids) (PILs), exploration of the effects of PIL topology, especially cyclic architecture, on bactericidal properties will expand the design possibilities for the development of excellent antibacterial surfaces. Herein, the preparation of antibacterial surfaces based on cyclic PIL brushes is reported for the first time and how the cyclic PIL architecture affects bactericidal activity is investigated. It is shown that the cyclic architecture imparted PIL brushes with enhanced bactericidal activity, achieving only 1.7% of bacterial viable percentage against gram-negative Escherichia coli using Live/Dead staining methods, compared to 6.6% for the corresponding linear PIL brushes. The enhanced bactericidal activity is also validated by the direct observation of scanning electron microscopy and a colony counting assay. Further mechanism studies reveal that the substantially different morphologies of cyclic aggregates and altered surface charge density induced by the cyclic PIL architecture can account for the enhanced bactericidal activity.

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This article was published in the following journal.

Name: Macromolecular rapid communications
ISSN: 1521-3927
Pages: e1900379

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Medical and Biotech [MESH] Definitions

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Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.

Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.

One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.

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