REVIEW: Obesity, neuroinflammation and reproductive function.

08:00 EDT 12th September 2019 | BioPortfolio

Summary of "REVIEW: Obesity, neuroinflammation and reproductive function."

The increasing occurrence of obesity has become a significant public health concern. Obese individuals have higher prevalence of heart disease, stroke, osteoarthritis, diabetes, and reproductive disorders. Reproductive problems include menstrual irregularities, pregnancy complications, and infertility due to anovulation, in women, and lower testosterone and diminished sperm count, in men. In particular, obese women have reduced levels of both gonadotropin hormones and, in obese men, lower testosterone is accompanied by diminished luteinizing hormone. Together these findings indicate central dysregulation of the hypothalamus-pituitary-gonadal axis, specifically at the level of the GnRH neuron function, which is the final brain output for the regulation of reproduction. Obesity is a state of hyperinsulinemia, hyperlipidemia, hyperleptinemia, and chronic inflammation. Herein, we review recent advances in our understanding of how these metabolic and immune changes affect hypothalamic function and regulation of GnRH neuron. In the latter part, we focus on neuroinflammation as a major consequence of obesity, and discuss findings that reveal that GnRH neurons are uniquely positioned to respond to inflammatory changes.


Journal Details

This article was published in the following journal.

Name: Endocrinology
ISSN: 1945-7170


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